Assemblies of differentiable segmented particles

• US 20040209376A1
• Filed: 05/06/2004
• Published: 10/21/2004
• Est. Priority Date: 10/01/1999
• Status: Abandoned Application

• Current Assignee: Surromed Incorporated (Thermo Fisher Scientific Luxembourg I SARL)
• Original Assignee: Surromed Incorporated (Thermo Fisher Scientific Luxembourg I SARL)
• Inventors: Natan, Michael J., Mallouk, Thomas E.
• Application Number:
  US10/840,604
• Publication Number:
  US 20040209376A1
• Time in Patent Office: Days
• US Class Current: 436/56
• CPC Class Codes: B01J 13/0047 containing a metal oxide
• CPC Class Codes: B01J 13/0091 Preparation of aerogels, e.g. xerogels
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/005 Beads
• CPC Class Codes: B01J 2219/00502 Particles of irregular geometry
• CPC Class Codes: B01J 2219/00513 Essentially linear supports
• CPC Class Codes: B01J 2219/00545 Colours
• CPC Class Codes: B01J 2219/00547 Bar codes
• CPC Class Codes: B01J 2219/00554 Physical means
• CPC Class Codes: B01J 2219/00596 Solid-phase processes
• CPC Class Codes: B01J 2219/00657 One-dimensional arrays
• CPC Class Codes: B01J 2219/0072 Organic compounds
• CPC Class Codes: B01J 2219/00722 Nucleotides
• CPC Class Codes: B01L 3/545 for laboratory containers
• CPC Class Codes: B22F 1/062 Fibrous particles
• CPC Class Codes: B22F 1/08 Metallic powder characterised by particles having an amorphous microstructure
• CPC Class Codes: B22F 2207/01 Composition gradients
• CPC Class Codes: B22F 2999/00 Aspects linked to processes or compositions used in powder metallurgy
• CPC Class Codes: B82B 1/00 Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• CPC Class Codes: B82Y 25/00 Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
• CPC Class Codes: B82Y 30/00 : Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C25D 1/04 : Wires; Strips; Foils
• CPC Class Codes: C40B 40/06 : Libraries containing nucleotides or polynucleotides, or derivatives thereof
• CPC Class Codes: C40B 70/00 : Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
• CPC Class Codes: G01N 33/54346 : Nanoparticles
• CPC Class Codes: H01F 1/0081 : in a non-magnetic matrix, e.g. Fe-nanowires in a nanoporous membrane
• CPC Class Codes: Y10T 436/13 : Tracers or tags

Abstract

Freestanding particles comprising a plurality of segments, wherein the particle length is from 10 nm to 50 μm and the particle width is form 5 nm to 50 μm.

Claims

1. An assembly of particles comprising a plurality of types of particles, wherein each particle is from 10 nm to 50 μ

m in length and is comprised of a plurality of segments, and wherein at least one of said types is differentiable from another of said types based on the sequence of said segments.

2. The assembly of particles of claim 1 wherein at least one of said types is differentiable from another of said types by optical means, electrical means, physical means, chemical means or magnetic means.

3. The assembly of particles of claim 2 wherein at least one of said types is differentiable from another of said types by optical means.

4. The assembly of particles of claim 3 wherein at least one of said types is differentiable from another of said types by differential reflectivity.

5. The assembly of particles of claim 1 wherein each said particle comprises 2 to 50 segments, and wherein the length of each particle is from 1 to 15 μ

m, the width of each particle is from 30 nm to 2 μ

m, and the segment lengths are from 50 nm to 10 μ

m.

6. The assembly of particles of claim 1 comprising functionalized particles.

7. The assembly of particles of claim 6 comprising at least one type that is differently functionalized from another type.

8. The assembly of particles of claim 6 wherein said functionalization comprises an organic substance, an inorganic substance, an inorganic coordination complex and/or an organometallic complex.

9. The assembly of particles of claim 6 wherein said functionalization comprises a detectable tag or a material which will bind a detectable tag.

10. The assembly of particles of claim 9 wherein said detectable tag is selected from the group consisting of:

a fluorescent tag, an isotopic tag, a radioactive tag, a particulate tag, an oligonucleotide-based tag, a molecular tag, a Raman-based tag, an infrared tag, a mass spectrometric tag, and an electrochemical tag.

11. An assembly of rod-shaped particles comprising a plurality of types of particles, wherein each particle has at least one dimension greater than about 10 nm and less than 10 μ

m, and wherein at least one of said types is differentiable from another of said types and is made by a process having different synthesis parameters from those of another of said types.

12. The assembly of particles of claim 11 wherein each particle has at least one dimension less than 500 nm.

13. The assembly of particle of claim 11 wherein each particle has at least one dimension less than 200 nm.

14. The assembly of particles of claim 11 comprising at least 3 types of particles.

15. The assembly of particles of claim 11 comprising at least 5 types of particles.

16. The assembly of particles of claim 11 wherein at least one of said types is differentiable from another of said types based on differences in particle length, width, and/or composition.

17. The assembly of particles of claim 11 comprising functionalized particles.

18. The assembly of particles of claim 17 comprising at least one type that is differently functionalized from another type.

19. The assembly of particles of claim 17 wherein said functionalization comprises an organic substance, an inorganic substance, an inorganic coordination complex and/or an organometallic complex.

20. The assembly of particles of claim 17 wherein said functionalization comprises a detectable tag or a material which will bind a detectable tag.

21. An assembly of particles comprising a plurality of each of a plurality of types of encoded particles, wherein each particle is from 10 nm to 50 μ

m in length and is comprised of a plurality of segments, and wherein at least one of said types is differentiable from another of said types based on said encoding.

22. The assembly of particles of claim 21 wherein said types are differentiable by at least one of optical means, electrical means, physical means, chemical means and magnetic means.

23. The assembly of particles of claim 22 wherein said types are differentiable by differential reflectivity.

24. The assembly of particles of claim 21 wherein each particle comprises 2 to 50 segments, and wherein the length of each particle is from 1 to 15 μ

m, the width of each particle is from 30 nm to 2 μ

m, and the segment lengths are from 50 nm to 10 μ

m.

25. The assembly of particles of claim 21 comprising functionalized particles.

26. The assembly of particles of claim 25 comprising types of particles differently functionalized from other types of particles.

27. The assembly of particles of claim 25 wherein said functionalization comprises at least one of an organic substance, an inorganic substance, an inorganic coordination complex, and an organometallic complex.

28. The assembly of particles of claim 25 wherein said functionalization comprises at least one of a detectable tag and a material that can bind a detectable tag.

29. The assembly of particles of claim 28 wherein said detectable tag comprises at least one of a fluorescent tag, an isotopic tag, a radioactive tag, a particulate tag, an oligonucleotide-based tag, a molecular tag, a Raman-based tag, an infrared tag, a mass spectrometric tag, and an electrochemical tag.

30. An assembly of particles comprising a plurality of types of particles, wherein each particle is from 10 nm to 50 μ

m in length and has a striping pattern, wherein said striping pattern is produced as a function of the sequence, composition, and length of segments of said particle, and wherein at least one of said types is differentiable from another of said types based on said striping pattern.

31. The assembly of particles of claim 30 wherein said types are differentiable by at least one of optical means, electrical means, physical means, chemical means and magnetic means.

32. The assembly of particles of claim 31 wherein said types are differentiable by differential reflectivity.

33. The assembly of particles of claim 30 wherein each particle comprises 2 to 50 segments, and wherein the length of each particle is from 1 to 15 μ

m, the width of each particle is from 30 nm to 2 μ

m, and the segment lengths are from 50 nm to 10 μ

m.

34. The assembly of particles of claim 30 comprising functionalized particles.

35. The assembly of particles of claim 34 comprising types of particles differently functionalized from other types of particles.

36. The assembly of particles of claim 34 wherein said functionalization comprises at least one of an organic substance, an inorganic substance, an inorganic coordination complex, and an organometallic complex.

37. The assembly of particles of claim 34 wherein said functionalization comprises at least one of a detectable tag and a material that can bind a detectable tag.

38. The assembly of particles of claim 37 wherein said detectable tag comprises at least one of a fluorescent tag, an isotopic tag, a radioactive tag, a particulate tag, an oligonucleotide-based tag, a molecular tag, a Raman-based tag, an infrared tag, a mass spectrometric tag, and an electrochemical tag.