Composition for in vivo vessel repair

• US 20040209998A1
• Filed: 01/02/2004
• Published: 10/21/2004
• Est. Priority Date: 01/02/2003
• Status: Active Grant

• Current Assignee: Alexander Cornelis De Vries
• Original Assignee: Vesalius N.V.
• Inventors: de Vries, Alexander Cornelis
• Granted Patent: US 7,670,622 B2
• Time in Patent Office: Days
• US Class Current: 524/862
• CPC Class Codes: A61K 31/80 Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 24/0094 containing macromolecular fillers
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

The present invention relates to a biocompatible polymer composition, suitable for in vivo vessel repair, comprising a matrix pre-polymer, a filler and a curing agent, wherein said composition wherein said biocompatible polymer composition is curable in the presence of a curing catalyst at 37° C. to form a cured material with an elongation until rupture of at least 5% and an elastic modulus of at least 1 MPa.

Claims

1. A biocompatible polymer composition, suitable for in vivo vessel repair, comprising a matrix pre-polymer, a filler and a curing agent, wherein said composition has a viscosity of 2 000 to 12 000 cSt at 25°

C. and wherein said biocompatible polymer composition is curable in the presence of a curing catalyst at 37°

C. to form a cured material with an elongation until rupture of at least 5% and an elastic modulus of at least 1 mpa.

2. Composition according to claim 1, wherein the viscosity of the biocompatible polymer composition is in the range of 3 000 to 10 000 cSt, preferably of 4 000 to 8 000 cSt.

3. Composition according to claim 1, wherein said biocompatible polymer composition is curable in the presence of a curing catalyst at 37°

C. to form a cured material with an elongation until rupture of at least 10%, preferably at least 25%.

5. Composition according to claim 1, wherein the filler is a hydrophobic filler.

7. Composition according to claim 1, wherein the biocompatible polymer composition comprises a curing-inhibitor.

16. Kit of parts suitable for use in an in vivo vessel repair, comprising a biocompatible polymer composition according to claim 1, and a curing-catalyst composition.

17. Kit according to claim 1, wherein the curing catalyst composition comprises at least one component selected from the group consisting of matrix pre-polymers, fillers and contrast agents.

18. Kit according to claim 1, wherein the viscosity of the curing catalyst composition is at most 1 500 cSt higher or lower than the viscosity of the biocompatible polymer composition.

19. Kit according to claim 1, wherein the biocompatible polymer composition mixed with the curing catalyst composition, has a curing time of 5 min or less, preferably of less than 3 min.

20. Use of a composition according to claim 1, in the manufacture of a physiologically acceptable composition for the in vivo repair of an aneurysm, preferably an aortic aneurysm.

21. Use of a composition according to claim 1, in the manufacture of a physiologically acceptable composition for prophylactic treatment of a bone, preferably a hip or a collarbone.

22. Use of a composition according to claim 1, in the manufacture of a physiologically acceptable composition for securing a stent or stent-graft in an artery.

23. Cured material, obtainable by curing a composition according to claim 1.

4. (canceled)

6. (canceled)

8-15. -15. (canceled)