Effect of electric field and ultrasound for transdermal drug delivery
First Claim
1. A method for enhancing transdermal transport of compounds comprising administering to the skin an effective amount of low frequency ultrasound to induce cavitation of the skin to enhance transport without increasing skin temperature more than about two degrees Centrigrade in combination with an effective amount of an electric field selected from the group consisting of iontophoresis and electroproration to enhance transport.
2 Assignments
0 Petitions
Accused Products
Abstract
Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by application of an electric field, for example, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layers of the stratum corneum (SC). This method provides higher drug transdermal fluxes, allows rapid control of transdermal fluxes, and allows drug delivery or analyte extraction at lower ultrasound intensities than when ultrasound is applied in the absence of an electric field.
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Citations
24 Claims
- 1. A method for enhancing transdermal transport of compounds comprising administering to the skin an effective amount of low frequency ultrasound to induce cavitation of the skin to enhance transport without increasing skin temperature more than about two degrees Centrigrade in combination with an effective amount of an electric field selected from the group consisting of iontophoresis and electroproration to enhance transport.
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2. (Canceled).
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7. (Canceled).
- 12. An apparatus, comprising a means for applying low frequency ultrasound to induce cavitation of the skin to enhance transport without increasing skin temperature more than about two degrees Centrigrade and a means for applying ant electric field in a form selected from the group consisting of iontophoresis and electroporation to skin in an amount effective to enhance transport of molecules trough the skin without damaging the skin.
Specification