Antithrombotic compositions and medical instruments containing the same
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Abstract
The present invention provides an antithrombotic composition containing an ionic complex formed from an organic cation mixture and heparin or a heparin derivative, wherein the organic cation mixture is a mixture of at least two ammonium salts, provided that the above-mentioned organic cation mixture is not a mixture of a didodecyldimethylammonium salt and at least one kind of an ammonium salt selected from ammonium salts having four aliphatic groups, wherein the four aliphatic groups have 30 to 38 carbon atoms in total and at least two of the four aliphatic groups are each an alkyl group having not less than 10 carbon atoms. This antithrombotic composition can impart superior antithrombotic property to a medical device over a prolonged period.
17 Citations
27 Claims
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1-9. -9. (canceled)
- 10. An an tithrombotic composition comprising an ionic complex formed from an organic cation mixture and heparin or a heparin derivative, wherein the organic cation mixture is a mixture of at least two ammonium salts, provided that said organic cation mixture is not a mixture of a didodecyldimethylammonium salt and at least one kind of an ammonium salt selected from ammonium salts having four aliphatic groups, wherein the four aliphatic groups have 30 to 38 carbon atoms in total and at least two of the four aliphatic groups are each an alkyl group having not less than 10 carbon atoms.
Specification