Patterned, high surface area substrate with hydrophilic/hydrophobic contrast, and method of use
First Claim
1. A method of forming discrete hydrophilic regions on a substrate, comprising:
- depositing a layer onto a substrate, wherein the layer includes a matrix material and a porogen;
crosslinking the matrix material to form a nanohybrid composite structure out of the matrix material and the porogen;
decomposing the porogen to form pores within the matrix material; and
patternwise directing a reactive gas phase species onto a surface of the matrix material to form therein discrete regions that are more hydrophilic than are other regions in the material that are adjacent to said discrete regions, said discrete regions and said other regions extending from the surface of the material into the material beneath the surface.
1 Assignment
0 Petitions
Accused Products
Abstract
Nanoporous structures are constructed that have hydrophilic regions separated by hydrophobic regions. The porous, hydrophilic regions have reaction sites suitable for use in a bioassay application and have a higher density of reaction sites than that of a non-porous (2-D) surface. The structure may be made by depositing a layer of a matrix material (e.g., an organosilicate) and a porogen, and then crosslinking the matrix material to form a nanohybrid composite structure. The porogen is decomposed to form pores within the matrix material, and a reactive gas phase species (e.g., ozone) is patternwise directed onto a surface of the matrix material. Ultraviolet light (directed through a mask) activates the gas phase species to form a reactive species that then reacts with the matrix material to make it hydrophilic. The porogen may be decomposed thermally or by exposing it to an oxidizing atmosphere in the presence of ultraviolet light.
-
Citations
40 Claims
-
1. A method of forming discrete hydrophilic regions on a substrate, comprising:
- depositing a layer onto a substrate, wherein the layer includes a matrix material and a porogen;
crosslinking the matrix material to form a nanohybrid composite structure out of the matrix material and the porogen;
decomposing the porogen to form pores within the matrix material; and
patternwise directing a reactive gas phase species onto a surface of the matrix material to form therein discrete regions that are more hydrophilic than are other regions in the material that are adjacent to said discrete regions, said discrete regions and said other regions extending from the surface of the material into the material beneath the surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- depositing a layer onto a substrate, wherein the layer includes a matrix material and a porogen;
-
20. A method of forming regions of varying hydrophilicity on a substrate, comprising:
-
depositing a layer onto a substrate, wherein the layer includes a matrix material and a porogen;
crosslinking the matrix material to form a nanohybrid composite structure out of the matrix material and the porogen;
thermally decomposing the porogen to form pores in the layer; and
patternwise oxidizing the matrix material to form regions of varying hydrophilicity within the layer, wherein said regions extend from a surface of the material into the material. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28)
-
-
29. A method of forming regions of varying hydrophilicity on a substrate, comprising:
-
depositing a layer onto a substrate, wherein the layer includes a matrix material and a porogen;
crosslinking the matrix material to form a nanohybrid composite structure out of the matrix material and the porogen;
patternwise directing, in the presence of an oxidizing species, ultraviolet radiation onto selected regions of the matrix material to both decompose the porogen and induce hydrophilicity within said selected regions, wherein said selected regions extend from a surface of the matrix material into the material. - View Dependent Claims (30, 31, 32, 33, 34)
-
- 35. A nanoporous structure having regions of varying hydrophilicity, said regions corresponding to a preselected pattern, the structure including pores having a minimum characteristic dimension of between 2 nm and 75 nm, said pores constituting at least 5% of said structure by volume.
Specification