Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution
First Claim
Patent Images
1. A method of measuring in absolute physical units at least one parameter of the cardiovascular system of a subject comprising:
- administering to the cardiovascular system of a subject a detectable amount of at least one indicator;
applying a first wavelength of light for exciting the indicator within the cardiovascular system and causing the indicator to emit a second wavelength of light, measuring the intensity of the second wavelength of light emitted from the indicator in the circulatory system using at least one photodetector proximately located to a detection area of the subject;
determining the magnitude of the at least one parameter of the cardiovascular system in absolute physical units based on the measured intensity of the second wavelength of light.
1 Assignment
0 Petitions
Accused Products
Abstract
A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection methods is disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health.
-
Citations
28 Claims
-
1. A method of measuring in absolute physical units at least one parameter of the cardiovascular system of a subject comprising:
-
administering to the cardiovascular system of a subject a detectable amount of at least one indicator;
applying a first wavelength of light for exciting the indicator within the cardiovascular system and causing the indicator to emit a second wavelength of light, measuring the intensity of the second wavelength of light emitted from the indicator in the circulatory system using at least one photodetector proximately located to a detection area of the subject;
determining the magnitude of the at least one parameter of the cardiovascular system in absolute physical units based on the measured intensity of the second wavelength of light. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 24)
-
-
14. A system for measuring in absolute physical units at least one parameters of the cardiovascular system of a subject comprising:
-
an illumination source configured to be positioned proximately to at least one blood vessel of the cardiovascular system for providing a first wavelength of light for exciting an indicator within the cardiovascular system and causing the indicator to emit a second wavelength of light;
a photodetector configured to be positioned proximate to at least one blood vessel of the cardiovascular system of the subject for detecting the magnitude of intensity of the second wavelength of light emitted from the indicator in the cardiovascular system and to generate electronic signals to indicative of the detected magnitude of intensity of the second wavelength of light;
a computing system configured to receive the electronic signals and to compute the magnitude of the at least one parameter of the cardiovascular system of the subject in absolute physical units based on the electronic signals. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
-
-
25. A method of measuring cardiac output of a subject comprising:
-
administering a detectable amount of at least one indicator to the cardiovascular system of a subject;
applying a first wavelength of light for exciting the indicator within the cardiovascular system and causing the indicator to emit a second wavelength of light;
measuring the intensity of the second wavelength of light emitted from the indicator in the circulatory system using at least one photodetector proximately located to a detection area of the subject; and
determining the magnitude of the cardiac output based on the measured intensity of the second wavelength of light. - View Dependent Claims (26)
-
-
27. A method of measuring blood volume in a subject comprising:
-
administering a detectable amount of at least one indicator to the cardiovascular system of a subject;
applying a first wavelength of light for exciting the indicator within the cardiovascular system and causing the indicator to emit a second wavelength of light;
measuring the intensity of the second wavelength of light emitted from the indicator in the circulatory system using at least one photodetector proximately located to a detection area of the subject; and
determining the magnitude of the blood volume based on the measured intensity of the second wavelength of light. - View Dependent Claims (28)
-
Specification