Pacemaker with improved capability for detecting onset of tachyarrhythmias and heart failure

• US 20040215238A1
• Filed: 04/24/2003
• Published: 10/28/2004
• Est. Priority Date: 04/24/2003
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: van Oosterom, Adriaan, van Dam, Peter M.
• Application Number:
  US10/422,712
• Publication Number:
  US 20040215238A1
• Time in Patent Office: Days
• US Class Current: 607/4
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

The invention provides a system and method for determining cardiac condition by examining the width of cardiac excitation waves sensed by a tip electrode. In one embodiment, an atrial lead with a tip electrode is positioned against the inside of the atrial wall, and senses passing depolarization (P-wave) waves. The sensed signals are processed to determine effective duration, and then analyzed to determine if there has been a change in conduction velocity. A predetermined decrease in conduction velocity is interpreted to mean that the atrium is at the onset of AF and appropriate atrial pacing therapy is initiated. In a second embodiment, a lead with a tip electrode is positioned adjacent to the left free ventricular wall and R wave durations are obtained. For substantially constant ventricular conduction conditions, R wave duration variations are analyzed to determine ventricular wall thickening of a degree that indicates onset of chronic heart failure.

Claims

1. An implantable cardiac treatment system for predicting the onset of an atrial arrhythmia, comprising a pacemaker device and a lead,

said lead having a tip electrode adapted to be positioned against the myocardial wall of the patient'"'"'s right atrium to sense P-waves and having conducting means for conducting sensed P-waves,

said pacemaker device comprising:

receiving means for receiving said sensed P-waves from said lead conducting means;

processing means for processing sensed P-waves to obtain a measure of the P-wave signal width of each processed P-wave;

monitoring means for monitoring said width measures over a long period to determine the onset of atrial fibrillation (AF); and

response means for responding to a determination of onset of AF by providing a predetermined AF pacing therapy.

2. The system as described in claim 1, wherein said processing means comprises determining means for operating on a P-wave to determine the signal width in milliseconds between two predetermined reference points on said P-wave.

3. The system as described in claim 2, wherein said determining means comprises amplitude means for determining the maximum amplitude of a processed P-wave signal and reference means for setting said reference points relative to said maximum amplitude.

4. The system as described in claim 3, wherein said reference means comprises means for setting said reference points where the leading and trailing edges of said P-wave are a predetermined fraction below said maximum amplitude.

5. The system as described in claim 3, wherein said amplitude means further comprises minimum means for determining the minimum amplitude of a processed P-wave, and said reference means comprises means for setting said reference points where the leading and trailing edges of said P-wave are a predetermined distance between said maximum and minimum amplitudes.

6. The system as described in claim 1, comprising storage means for storing data representative of said width measures over said long period.

7. The system as described in claim 6, wherein said response means comprises means for evaluating said stored data and for determining the presence or absence of AF onset as a function of said evaluated data.

8. The system as described in claim 6, wherein said response means comprises means for evaluating said stored data over a period of at least a week and for determining the presence or absence of AF onset as a function of said evaluated data.

9. The system as described in claim 6, comprising evaluating means for evaluating said stored data to determine when said width measure has increased by a predetermined percentage.

10. A system for continuously determining a characteristic of a depolarization wave in a wall of a patient'"'"'s heart and for initiating a pacing response to the heart as a function of said determining, comprising:

signal means for obtaining a signal representative of the passage of a depolarization wave past a point on said wall;

Δ

t means for determining a measure of the signal width of the depolarization wave from each said obtained signal;

analyzing means for analyzing said signal width measures and for determining when said time width measures indicate a dangerous condition in said heart; and

response means for initiating a pacing therapy in response to a said dangerous condition.

11. The system as described in claim 10, wherein said signal means comprises a tip electrode positioned against the right atrial wall of said heart.

12. The system as described in claim 10, wherein said analyzing means comprises velocity means for determining conduction velocity in said heart.

13. The system as described in claim 12, wherein said velocity means comprises criteria means for comparing said signal width measures with predetermined criteria.

14. The system as described in claim 10, wherein said signal means comprises a tip electrode positioned adjacent to the patient'"'"'s left free ventricular wall.

15. The system as described in claim 14, wherein said analyzing means comprises wall thickness means for determining from said signal width measures when the patient'"'"'s left free ventricular wall has thickened to a dangerous value.

16. The system as described in claim 15, wherein said wall thickness means comprises criteria means for comparing said signal width measures with predetermined criteria.

17. The system as described in claim 10, wherein said signal means further comprises stability means for determining whether said signals are stable.

18. The system as described in claim 17, comprising rate means for limiting the operation of said system to conditions where the cardiac rate is within a predetermined range.

19. The system as described in claim 11, comprising threshold means for determining a velocity threshold, comparison means for comparing said conduction velocity with said threshold, and wherein said response means is enabled when conduction velocity is determined to be slower than said threshold.

20. The system as described in claim 19, wherein said threshold means comprises set means for setting said threshold as a function of signal width measures.

21. The system as described in claim 20, wherein said threshold means comprises programmable threshold criteria.

22. A method of determining a potentially dangerous condition of a patient'"'"'s heart, comprising:

positioning a tip electrode against the inside wall of a chamber of said heart;

obtaining from said tip electrode wave duration signals representative of the time width of passing depolarization waves, and storing data from said signals;

processing said signals to determine a significant change in the time width of said passing depolarization waves; and

indicating a said potentially dangerous condition when a said significant change is determined.

23. The method as described in claim 22, comprising positioning a lead with a tip electrode within the patient'"'"'s right atrium, and obtaining wave duration signals representative of the time width of depolarization waves in the right atrium as they pass said tip electrode.

24. The method as described in claim 23, wherein said processing comprises checking the sensed waveforms to determine that they are distinguished from noise.

25. The method as described in claim 24, wherein said processing comprises storing data representative of waveform duration in velocity categories, and comparing sensed data with said stored data to determine that said sensed data is within the range of said stored data.

26. The method as described in claim 25, comprising calculating from said stored data values representative of average conduction velocity, and comparing said average velocity values with predetermined criteria.

27. The method as described in claim 26, comprising determining a velocity threshold, and comparing each value of average conduction velocity with said threshold.

28. The method as described in claim 27, comprising determining when said average conduction velocity is less than said threshold, and initiating therapy in response to a said determination.

29. The method as described in claim 22, comprising positioning a tip electrode adjacent to the patient'"'"'s left free ventricular wall, and obtaining waveforms of passing ventricular depolarization waves.

30. The method as described in claim 29, comprising processing said obtained waveforms to obtain a measure of the duration of each, and storing data representative of said duration measures.

31. The method as described in claim 30, comprising storing time information with said stored duration data.

32. The method as described in claim 31, comprising comparing said duration data with predetermined criteria.

33. The method as described in claim 32, wherein said criteria comprises a predetermined value, and indicating a significant increase in left ventricular wall thickness when said duration measure is greater than said predetermined value.

34. The method as described in claim 29, comprising placing a lead with a tip electrode within the patient'"'"'s right ventricle and positioning said tip electrode against the ventricular wall, and obtaining reference depolarization waveforms from said right ventricle.

35. The method as described in claim 34, comprising determining from said reference waveforms whether ventricular conduction velocity has changed significantly and verifying an indication of significant increase in left ventricular wall thickness when said ventricular conduction velocity has not changed significantly.

36. The method as described in claim 35, comprising initiating therapy in response to an indication of increase in ventricular wall thickness.

37. An implantable system for obtaining a measure of relative conduction velocity in a patient'"'"'s atria, comprising:

a lead that carries a tip electrode, adapted to be positioned within the patient'"'"'s right atrium with said tip electrode snug against the inside wall of said atrium;

sensing means for obtaining from said tip electrode wave samples of depolarization waves that pass said tip electrode;

processing means for processing said wave samples to obtain measures of relative conduction velocity; and

analyzing means for analyzing said measures to provide an indication of change in conduction velocity in said patient'"'"'s atria.

38. The system as described in claim 37, wherein said processing means comprises duration means for obtaining for each said waveform a measure of the duration of said waveform.

39. The system as described in claim 38, wherein said duration means comprises means for determining a maximum value of the waveform, and measuring means for measuring said duration as the time duration between points on the waveform between values that are a predetermined percentage of said maximum value.

40. The system as described in claim 39, comprising storage means for storing data representative of said duration measures.

41. The system as described in claim 40, comprising threshold means for determining from said stored data a threshold value representative of a conduction velocity threshold.

42. The system as described in claim 41, comprising current means for determining a measure of current conduction velocity, and comparing means for comparing said current measure with said threshold value.

43. The system as described in claim 37, comprising initial means for determining and storing a measure of initial relative conduction velocity.

44. The system as described in claim 43, comprising current means for determining a measure of current conduction velocity from collected waveforms, and comparing means for comparing said current measure with said initial measure.

45. The system as described in claim 37, comprising checking means for checking the reliability of said wave samples in terms of indicating relative conduction velocity.

46. The system as described in claim 45, wherein said checking means comprises noise comparison means for determining that said waveforms are of significant amplitude above the prevailing noise level.

47. The system as described in claim 46, wherein said checking means comprises rate means for determining that the rate of said wave samples is within a predetermined range.

48. The system as described in claim 37, comprising sample means for determining that the collected number of waveform samples is sufficient to provide an accurate result.

49. A multi-chamber pacing system having leads postionable in a patient'"'"'s heart, comprising:

wall thickness means for obtaining a measure of left ventricular wall thickness;

wall analysis means for determining when the patient'"'"'s left ventricular wall has thickened unacceptably;

atrial velocity means for obtaining a measure of atrial conduction velocity; and

atrial velocity analysis means for determining when the patient'"'"'s atrial conduction velocity has slowed unacceptably.

50. The system as described in claim 49, further comprising ventricular velocity means for obtaining a measure of ventricular conduction velocity, and ventricular velocity analysis means for analyzing changes in ventricular conduction velocity.