Identifying combinations of electrodes for neurostimulation therapy

• US 20040215288A1
• Filed: 04/25/2003
• Published: 10/28/2004
• Est. Priority Date: 04/25/2003
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Goetz, Steven M., Lee, Michael T., Torgerson, Nathan A.
• Granted Patent: US 7,463,928 B2
• Time in Patent Office: Days
• US Class Current: 607/48
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means
• CPC Class Codes: Y10S 128/903 Radio telemetry

Abstract

A programmer allows a clinician to identify combinations of electrodes from within an electrode set implanted in a patient that enable delivery of desirable neurostimulation therapy by an implantable medical device. The programmer executes an electrode combination search algorithm to select combinations of electrodes to test in a non-random order. According to algorithms consistent with the invention, the programmer may first identify a position of a first cathode for subsequent combinations, and then select electrodes from the set to test with the first cathode as anodes or additional cathodes based on the proximity of the electrodes to the first cathode. The programmer may store information for each combination tested, and the information may facilitate the identification of desirable electrode combinations by the clinician. The clinician may create neurostimulation therapy programs that include identified desirable program combinations.

Claims

1. A method comprising:

selecting a first electrode of a set of electrodes implanted in a patient to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient; and

automatically selecting a sequence of additional electrodes of the set to test for inclusion in the combination of electrodes according to locations of the additional electrodes relative to the first electrode.

2. The method of claim 1, wherein selecting a first electrode comprises receiving input from a user that identifies the first electrode.

3. The method of claim 1, wherein selecting a first electrode comprises:

identifying an initial position within the set;

controlling an implantable medical device to test one of the electrodes located at the initial position for inclusion in the combination as the first electrode; and

controlling the implantable medical device to test additional electrodes of the set for inclusion in the combination as the first electrode in an order determined based on the initial position.

4. The method of claim 3, wherein identifying an initial position within the set comprises:

identifying a configuration of the electrode set; and

identifying the initial position based on the configuration.

5. The method of claim 3, wherein the initial position is a central position within the set, and controlling the implantable medical device to test additional electrodes comprises controlling the implantable medical device to test the additional electrodes in an order based on decreasing proximity of the additional electrodes to the initial position.

6. The method of claim 1, further comprising controlling an implantable medical device to test the additional electrodes according to the sequence.

7. The method of claim 6, wherein the first electrode is a cathode for the combination, and controlling an implantable medical device to test the additional electrodes comprises controlling the implantable medical device to test the additional electrodes for inclusion of one of the additional electrodes as an anode for the combination.

8. The method of claim 6, wherein controlling an implantable medical device to test the additional electrodes comprises controlling the implantable medical device to test a plurality of combinations of electrodes, each of the combinations including the first electrode and at least one of the additional electrodes.

9. The method of claim 8, wherein controlling the implantable medical device to test a combination of electrodes comprises:

controlling the implantable medical device to deliver neurostimulation via the combination of electrodes;

controlling the implantable medical device to increase an amplitude of the neurostimulation until an indication to stop increasing the amplitude is received from a user;

storing a value of the amplitude at a time when the indication is received from the user as an amplitude value for the combination; and

storing rating information received from the user that describes at least one of the effectiveness of the delivery of neurostimulation at the stored amplitude value in addressing symptoms of the patient and a degree of side effects caused by delivery of neurostimulation at the stored amplitude value as rating information for the combination.

10. The method of claim 9, further comprising:

displaying a list of the tested electrode combinations ordered according to at least one of amplitude values and rating information stored for each of the tested combinations;

receiving a selection of one of the tested combinations made by the user from the list; and

storing information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

11. The method of claim 9, further comprising:

selecting one of the tested combinations based on the information; and

storing information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

12. The method of claim 9, wherein the user is one of a clinician and the patient.

13. The method of claim 6, wherein the first electrode is a first cathode, and controlling an implantable device to test the additional electrodes comprises:

identifying a subset of undesignated electrodes within the set based on orientation of the undesignated electrodes with the first cathode and a first anode; and

controlling the implantable medical device to test electrodes within the subset in an order based on decreasing proximity of the electrodes within the subset to the first electrode.

14. The method of claim 1, wherein the combination includes a most recently tested additional electrode, the method further comprising:

identifying untested electrodes that would be tested after the most recently tested additional electrode according to the sequence; and

storing information identifying additional combinations of electrodes that include the identified untested electrodes as part of neurostimulation therapy programs.

15. The method of claim 1, wherein automatically selecting a sequence of additional electrodes comprises automatically selecting the sequence of additional electrodes based on decreasing proximity of the additional electrodes to the first electrode.

16. A computer-readable medium comprising instructions that cause a processor to:

select a first electrode of a set of electrodes implanted in a patient to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient; and

automatically select a sequence of additional electrodes of the set to test for inclusion in the combination of electrodes according to locations of the additional electrodes relative to the first electrode.

17. The computer-readable medium of claim 16, wherein the instructions that cause a processor to select a first electrode comprise instructions that cause a processor to receive input from a user that identifies the first electrode.

18. The computer-readable medium of claim 16, wherein the instructions that cause a processor to select a first electrode comprise instructions that cause a processor to:

identify an initial position within the set;

control an implantable medical device to test one of the electrodes located at the initial position for inclusion in the combination as the first electrode; and

control the implantable medical device to test additional electrodes of the set for inclusion in the combination as the first electrode in an order determined based on the initial position.

19. The computer-readable medium of claim 16, wherein the instructions that cause a processor to identify an initial position within the set comprise instructions that cause a processor to:

identify a configuration of the electrode set; and

identify the initial position based on the configuration.

20. The computer-readable medium of claim 19, wherein the initial position is a central position within the set, and the instructions that cause a processor to control the implantable medical device to test additional electrodes comprise instructions that cause a processor to control the implantable medical device to test the additional electrodes in an order based on decreasing proximity of the additional electrodes to the initial position.

21. The computer-readable medium of claim 16, further comprising instructions that cause a processor to control an implantable medical device to test the additional electrodes according to the sequence.

22. The computer-readable medium of claim 21, wherein the first electrode is a cathode for the combination, and the instructions that cause a processor to control an implantable medical device to test the additional electrodes comprise instructions that cause a processor to control the implantable medical device to test the additional electrodes for inclusion of one of the additional electrodes as an anode for the combination.

23. The computer-readable medium of claim 21, wherein the instructions that cause a processor to control an implantable medical device to test the additional electrodes comprise instructions that cause a processor to control the implantable medical device to test a plurality of combinations of electrodes, each of the combinations including the first electrode and at least one of the additional electrodes.

24. The computer-readable medium of claim 23, wherein the instructions that cause a processor to control the implantable medical device to test a combination of electrodes comprise instructions that cause a processor to:

control the implantable medical device to deliver neurostimulation via the combination of electrodes;

control the implantable medical device to increase an amplitude of the neurostimulation until an indication to stop increasing the amplitude is received from a user;

store a value of the amplitude at a time when the indication is received from the user as an amplitude value for the combination; and

store rating information received from the user that describes at least one of the effectiveness of the delivery of neurostimulation at the stored amplitude value in addressing symptoms of the patient and a degree of side effects caused by delivery of neurostimulation at the stored amplitude value as rating information for the combination.

25. The computer-readable medium of claim 24, further comprising instructions that cause a processor to:

display a list of the tested electrode combinations ordered according to at least one of amplitude values and rating information stored for each of the tested combinations;

receive a selection of one of the tested combinations made by the user from the list; and

store information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

26. The computer-readable medium of claim 24, further comprising instructions that cause a processor to:

select one of the tested combinations based on the information; and

store information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

27. The computer-readable medium of claim 24, wherein the user is one of a clinician and the patient.

28. The computer-readable medium of claim 21, wherein the first electrode is a first cathode, and the instructions that cause a processor to control an implantable medical device to test the additional electrodes comprise instructions that cause a processor to:

identify a subset of undesignated electrodes within the set based on orientation of the undesignated electrodes with the first cathode and a first anode; and

control the implantable medical device to test electrodes within the subset in an order based on decreasing proximity of the electrodes within the subset to the first electrode.

29. The computer-readable medium of claim 16, wherein the combination includes a most recently tested additional electrode, further comprising instructions that cause a processor to:

identify untested electrodes that would be tested after the most recently tested additional electrode according to the sequence; and

store information identifying additional combinations of electrodes that include the identified untested electrodes as part of neurostimulation therapy programs.

30. The computer-readable medium of claim 16, wherein the instructions that cause a processor to automatically select the sequence of additional electrodes comprise instructions that cause a processor to automatically select the sequence of additional electrodes based on decreasing proximity of the additional electrodes to the first electrode.

43. The device of claim 30, further comprising a memory, wherein the combination includes a most recently tested additional electrode, and the processor identifies untested electrodes that would be tested after the most recently tested additional electrode according to the order, and stores information identifying additional combinations of electrodes that include the identified untested electrodes as part of neurostimulation therapy programs in the memory.

44. The device of claim 30, wherein the processor automatically selects of sequence of additional electrodes to test based on decreasing proximity of the additional electrodes to the first electrode.

45. The device of claim 30, wherein the device comprises a programming device associated with one of a clinician and the patient.

31. A device comprising a processor to select a first electrode of a set of electrodes implanted in a patient to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient, and automatically select a sequence of additional electrodes of the set to test for inclusion in the combination of electrodes according to locations of the additional electrodes relative to the first electrode.

32. The device of claim 31, wherein the processor receives input from a user that identifies the first electrode.

33. The device of claim 31, wherein the processor identifies an initial position within the set, controls the implantable medical device to test one of the electrodes located at the initial position for inclusion in the combination as the first electrode, and controls the implantable medical device to test additional electrodes of the set for inclusion in the combination as the first electrode in an order determined based on the initial position.

34. The device of claim 33, wherein the processor identifies a configuration of the electrode set, and identifies the initial position based on the configuration.

35. The device of claim 33, wherein the initial position is a central position within the set, and the processor controls the implantable medical device to test the additional electrodes in an order based on decreasing proximity of the additional electrodes to the initial position.

36. The device of claim 31, wherein the processor controls an implantable medical device to test the additional electrodes according to the sequence.

37. The device of claim 36, wherein the first electrode is a cathode for the combination, and the processor controls the implantable medical device to test the additional electrodes for inclusion of one of the additional electrodes as an anode for the combination.

38. The device of claim 36, wherein the processor controls the implantable medical device to test a plurality of combinations of electrodes, each combination including the first electrode and at least one additional electrode.

39. The device of claim 38, further comprising a memory, wherein the processor controls the implantable medical device to test a combination of electrodes by controlling the implantable medical device to deliver neurostimulation via the combination of electrodes, controlling the implantable medical device to increase an amplitude of the neurostimulation until an indication to stop increasing the amplitude is received from a user, storing a value of the amplitude at a time when the indication is received from the user as an amplitude value for the combination in the memory, and storing rating information received from the user that describes at least one of the effectiveness of the delivery of neurostimulation at the stored amplitude value in addressing symptoms of the patient and a degree of side effects caused by delivery of neurostimulation at the stored amplitude value in the memory as rating information for the combination.

40. The device of claim 39, wherein the processor displays a list of the tested electrode combinations ordered according to at least one of amplitude values and rating information stored for each of the tested combinations, receives a selection of one of the tested combinations made by the user from the list, and stores information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

41. The device of claim 39, wherein the processor selects one of the tested combinations based on the information, and stores information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

42. The device of claim 36, wherein the first electrode is a first cathode, and wherein the processor identifies a subset of undesignated electrodes within the set based on orientation of the undesignated electrodes with the first cathode and a first anode, and controls the implantable medical device to test electrodes within the subset in an order based on decreasing proximity of the electrodes within the subset to the first electrode.

46. A method comprising:

executing a search algorithm to control an implantable medical device to test combinations of electrodes in an order that is based on proximity of the electrodes of the combinations to a central position within the set; and

storing information identifying at least one of the tested combinations as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

47. The method of claim 46, further comprising:

receiving input from a user identifying a configuration of the electrode set; and

selecting the search algorithm based on the configuration.

48. The method of claim 46, wherein each of the combinations includes a common first cathode, and controlling an implantable medical device to test combinations of electrodes in an order comprises controlling the implantable medical device to test combinations of electrodes in an order based on proximity of other electrodes of the combinations to the first cathode.

49. The method of claim 48, further comprising controlling the implantable medical device to test electrodes of the set in an order based on decreasing proximity to the central position for identification of the first cathode.