Implantable lead with dissolvable coating for improved fixation and extraction
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Abstract
A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.
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Citations
72 Claims
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1-35. -35. (Canceled).
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36. An apparatus comprising:
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an implantable device including a peripheral surface; and
an at least partially dissolvable coating at least partially on a portion of the peripheral surface of the device body, the coating initially providing a slippery lubricating surface after being exposed to an aqueous substance, and then later providing at least one of a rough surface and a porous surface after being exposed to the aqueous substance, the at least one of the rough and the porous surface allowing tissue ingrowth. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44)
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45. An apparatus comprising:
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an implantable device including a peripheral surface that is sized and shaped to be inserted into at least one of a coronary sinus and a great cardiac vein; and
an at least partially dissolvable coating at least partially on a portion of the peripheral surface of the device body, the coating providing at least one of a rough surface and a porous surface after being exposed to the aqueous substance, the at least one of the rough and the porous surface allowing tissue ingrowth. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52)
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53. An apparatus comprising:
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an implantable device including a peripheral surface; and
an at least partially dissolvable coating at least partially on a portion of the peripheral surface of the device body, the coating including a therapeutic agent disposed in a medium that is permeable by water vapor. - View Dependent Claims (54, 55, 56, 57, 58, 59, 60, 61, 62)
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63. An apparatus comprising:
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an implantable device including a peripheral surface; and
an at least partially dissolvable coating at least partially on a portion of the peripheral surface of the device body, the coating providing at least one of a rough surface and a porous surface after being exposed to the aqueous substance, the coating including two therapeutic agents with different release rates. - View Dependent Claims (64, 65, 66)
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67. An apparatus comprising:
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an implantable device including a peripheral surface; and
an at least partially dissolvable coating at least partially on a portion of the peripheral surface of the device body, the coating providing at least one of a rough surface and a porous surface after being exposed to the aqueous substance, the coating including at least one therapeutic agent and at least one lubricating agent. - View Dependent Claims (68, 69, 70, 71, 72)
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Specification