Method and system for drug delivery to abdominal aortic or thoracic aortic aneurysms

• US 20040215338A1
• Filed: 04/24/2003
• Published: 10/28/2004
• Est. Priority Date: 04/24/2003
• Status: Abandoned Application

• Current Assignee: Medtronic Vascular (Medtronic Plc)
• Original Assignee: Medtronic Vascular (Medtronic Plc)
• Inventors: Tseng, David, Hathaway, Sandra K., Letort, Michel, Elkins, Jeff
• Application Number:
  US10/422,638
• Publication Number:
  US 20040215338A1
• Time in Patent Office: Days
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/89 the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
• CPC Class Codes: A61F 2002/065 Y-shaped blood vessels
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

The methods and devices for delivering therapeutic agents to abdominal aortic or thoracic aortic aneurysms provide a coated stent graft and methods of using the same. The coated stent graft system 100 comprises a support 20 and graft material 40 attached to the support 20, with a coating 30, 35 including a therapeutic agent disposed on the support 20 and/or the graft material 40. The coated stent graft system 600 can also include a stent graft portion 605 with an agent delivery portion 655 disposed about the stent graft portion 605 and including a therapeutic agent. A stent graft drug delivery system can include an endovascular catheter 710 having a coated region 730 with a therapeutic agent, and a stent graft 705 disposed on the endovascular catheter 710. The endovascular catheter 710 can have a balloon for releasing the therapeutic agent. The therapeutic agent can be injected by endovascular catheter on carrier particles.

Claims

1. A stent graft system, comprising:

.

a support 20;

a graft material 40 attached to the support 20; and

a graft material coating 35 disposed on the graft material 40, the graft material coating 35 including a therapeutic agent.

2. The stent graft system of claim 1 wherein the graft material coating 35 is disposed on the graft material 40 in a manner selected from the group consisting of being dispersed on the graft material 40 and being impregnated within the graft material 40.

3. The stent graft system of claim 1 wherein the therapeutic agent is selected from the group consisting of an antibiotics, doxycycline, rifampicin, propranolol, beta-adrenergic blockades, MMP activity inhibitors, elastin degradation preventatives, anti-inflammatory agents, analgesics, and anti-dilation agents.

4. The stent graft system of claim 1 wherein the support 20 is constructed from at least one material selected from the group consisting of biocompatible metal, implantable quality stainless steel wire, nitinol, nickel and titanium alloy, and biocompatible plastic.

5. The stent graft system of claim 1 wherein the graft material 40 is constructed from at least one material selected from the group consisting of biocompatible plastic, implantable quality woven polyester, collagen, albumin, absorbable polymer, biocompatible fiber, and biocompatible metal.

6. The stent graft system of claim 1 wherein the graft material 40 has an inside and an outside, the graft material coating 35 being dispersed on the outside of the graft material 40 and the inside of the graft material 40 being uncoated.

7. The stent graft system of claim 1 wherein the graft material coating 35 includes a carrier.

8. The stent graft system of claim 7 wherein the carrier comprises at least one component selected from the group consisting of biodegradable polymers, succinated gelatin, polylactic acid, polyglycolic acid, collagen, proteins, synthetic polymers, non-degradable microparticulates, non-degradable nanoparticulates, biodegradable microparticulates, biodegradable nanoparticulates, thermoplastic polyesters, and copolymers of lactide and glycolide.

9. The stent graft system of claim 1 wherein the graft material 40 has a first portion and a second portion, the graft material coating 35 being disposed on the first portion and the second portion being uncoated.

10. A stent graft system, comprising:

a support 20;

a graft material 40 attached to the support 20; and

a support coating 30 disposed on the support 20, the support coating 30 including a therapeutic agent.

11. The stent graft system of claim 10 wherein the support coating 30 is disposed on the support 20 in a manner selected from the group consisting of being dispersed on the support 20 and being impregnated within the support 20.

12. The stent graft system of claim 10 wherein the therapeutic agent is selected from the group consisting of antibiotics, doxycycline, rifampicin, propranolol, beta-adrenergic blockades, MMP activity inhibitors, elastin degradation preventatives, anti-inflammatory agents, analgesics, and anti-dilation agents.

13. The stent graft system of claim 10 wherein the support 20 is constructed from at least one material selected from the group consisting of biocompatible metal, implantable quality stainless steel wire, nitinol, nickel and titanium alloy, and biocompatible plastic.

14. The stent graft system of claim 10 wherein the graft material 40 is constructed from at least one material selected from the group consisting of biocompatible plastic, implantable quality woven polyester, collagen, albumin, absorbable polymer, biocompatible fiber, and biocompatible metal.

15. The stent graft system of claim 10 wherein the support 20 has an inside and an outside, the support coating 30 being dispersed on the outside of the support 20 and the inside of the support 20 being uncoated.

16. The stent graft system of claim 10 wherein the support coating 30 includes a carrier.

17. The stent graft system of claim 16 wherein the carrier comprises at least one component selected from the group consisting of biodegradable polymers, succinated gelatin, polylactic acid, polyglycolic acid, collagen, proteins, synthetic polymers, non-degradable microparticulates, non-degradable nanoparticulates, biodegradable microparticulates, biodegradable nanoparticulates, thermoplastic polyesters, and copolymers of lactide and glycolide.

18. The stent graft system of claim 10 wherein the support 20 has a first portion and a second portion, the support coating 30 being disposed on the first portion and the second portion being uncoated.

19. A coated stent graft system comprising:

a stent graft portion 605; and

an agent delivery portion 655, the agent delivery portion 655 able to be disposed about the stent graft portion 605 and including a therapeutic agent.

20. The coated stent graft system of claim 19 wherein the therapeutic agent is selected from the group consisting of an antibiotics, doxycycline, rifampicin, propranolol, beta-adrsnergic blockades, MMP activity inhibitors, elastin degradation preventatives, anti-inflammatory agents, analgesics, and anti-dilation agents.

21. The coated stent graft system of claim 19 wherein the agent delivery portion 655 is constructed from at least one material selected from the group consisting of biodegradable polymers, succinated gelatin, polylactic acid, polyglycolic acid, collagen, proteins, synthetic polymers, non-degradable microparticulates, non-degradable nanoparticulates, biodegradable microparticulates, biodegradable nanoparticulates, thermoplastic polyesters, and copolymers of lactide and glycolide.

22. A stent graft drug delivery system comprising:

an endovascular catheter 710, the endovascular catheter 710 having a coated region 730, the coated region 730 including a therapeutic agent; and

a stent graft 705 disposed on the endovascular catheter 710.

23. The stent graft drug delivery system of claim 22 wherein the stent graft 705 is a coated stent graft.

24. The stent graft drug delivery system of claim 22 wherein the therapeutic agent is selected from the group consisting of antibiotics, doxycycline, rifampicin, propranolol, beta-adrenergic blockades, MMP activity inhibitors, elastin degradation preventatives, anti-inflammatory agents, analgesics, and anti-dilation agents.

25. The stent graft drug delivery system of claim 22 wherein the graft material coating 35 includes at least one component selected from the group consisting of biodegradable polymers, succinated gelatin, polylactic acid, polyglycolic acid, collagen, proteins, synthetic polymers, non-degradable microparticulates, non-degradable nanoparticulates, biodegradable microparticulates, biodegradable nanoparticulates, thermoplastic polyesters, and copolymers of lactidel and glycolide.

26. The stent graft drug delivery system of claim 22 wherein the therapeutic agent is released by an event selected from the group consisting of a change in physical conditions and a physical action.

27. The stent graft drug delivery system of claim 22 wherein the endovascular catheter 710 has at least one balloon portion.

28. The stent graft drug delivery system of claim 27 wherein the coated region 730 is disposed on the balloon portion.

29. The stent graft drug delivery system of claim 27 wherein the stent graft 705 is disposed on the balloon portion.

30. The stent graft drug delivery system of claim 22 wherein the stent graft 705 is self-expanding.

31. A method for delivering a stent graft comprising:

providing an endovascular catheter having at least one coated region including a therapeutic agent, and a stent graft disposed on the endovascular catheter 800;

inserting the endovascular catheter into the patient 810;

releasing the therapeutic agent from the coated region 820; and

deploying the stent graft 830.

32. The method of claim 31 wherein the stent graft is a coated stent graft.

33. The method of claim 31 wherein the endovascular catheter has a balloon, the coated region is disposed on the balloon, and releasing the therapeutic agent from the coated region comprises inflating the balloon.

34. The method of claim 31 wherein the endovascular catheter has a balloon, the stent graft is disposed on the balloon, and deploying the stent graft comprises inflating the balloon.

35. A method for stent graft drug delivery at a target site comprising:

providing a stent graft 1000;

inserting the stent graft into the patient at the target site 1010;

deploying the stent graft 1020;

providing an endovascular catheter 1030;

inserting the endovascular catheter into the patient to the target site 1040; and

injecting carrier particles through the endovascular catheter to the target site 1050.

36. The method of claim 35 wherein the stent graft is a coated stent graft.

37. The method of claim 35 wherein injecting carrier particles through the endovascular catheter to the target site comprises injecting carrier particles through the endovascular catheter into an aneurysm.

38. The method of claim 35 wherein the carrier particles are made of a material selected from the group consisting of biodegradable polymers, polyvinyl alcohol, succinated gelatin, polylactic acid, polyglycolic acid, collagen, proteins, synthetic polymers, non-degradable microparticulates, non-degradable nanoparticulates, biodegradable microparticulates, biodegradable nanoparticulates, thermoplastic polyesters, and copolymers of lactide and glycolide.

39. The method of claim 35 wherein the carrier particles include a therapeutic agent selected from the group consisting of antibiotics, doxycycline, rifampicin, propranolol, beta-adrenergic blockades, MMP activity inhibitors, elastin degradation preventatives, anti-inflammatory agents, analgesics, and anti-dilation agents.

40. The method of claim 35 wherein providing a stent graft comprises providing a stent graft disposed on a balloon of a delivery catheter, and deploying the stent graft comprises inflating the balloon.

41. The method of claim 35 further comprising occluding a blood vessel upstream of the target site.

42. A method of manufacturing a coated stent graft comprising:

providing a support 1100;

providing graft material 1110;

attaching the graft material to the support to form a stent graft 1120; and

applying a therapeutic agent to at least one element selected from the group consisting of the support, the graft material, and the stent graft 1130.

43. The method of claim 42 further comprising curing the coated stent graft 1140.

44. The method of claim 42 wherein attaching the graft material to the support comprises attaching the graft material to the support by a method selected from the group consisting of sewing and gluing.

45. The method of claim 42 wherein the therapeutic agent is contained in a solvent/polymer solution.

46. The method of claim 42 wherein applying a therapeutic agent to at least one element comprises uniformly coating the element.

47. The method of claim 42 wherein applying a therapeutic agent to at least one element comprises coating a portion of the element.

48. The method of claim 42 wherein applying a therapeutic agent to at least one element comprises coating the element by a method selected from the group comprising rolling, dipping, spraying, printing, and ink jet printing.

49. A system for manufacturing a coated stent graft comprising:

means for attaching a graft material to a support to form a stent graft; and

means for applying a therapeutic agent to at least one element selected from the group consisting of the support, the graft material, and the stent graft.

50. The system of claim 49 further comprising means for curing the coated stent graft.