Thermogelling emulsions for sustained release of bioactive substances
First Claim
1. A temperature-sensitive thermogelling emulsion delivery system, comprising:
- a biodegradable temperature-sensitive aqueous phase polymer solution;
at least one bioactive substance, and a pharmaceutically acceptable oil phase carrier, said oil carrier embeds said bioactive substance;
wherein said oil phase carrier and said temperature-sensitive polymer solution are mixed mutually to form an emulsion, which is a liquid while at a temperature below a lower critical solution temperature (LCST) and transforms into a gel while the temperature of the emulsion is above said lower critical solution temperature (LCST).
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to a temperature-sensitive thermogelling emulsion system for bioactive substances, consisting of a biodegradable temperature-sensitive aqueous phase polymer solution, and a pharmaceutically acceptable oil phase carrier, which embeds the bioactive substance. The oil phase carrier and the temperature-sensitive polymer solution are mixed mutually to produce the emulsion, and the emulsion is a liquid while the temperature is below the lower critical solution temperature (LCST) and reversibly transforms into a gel while the temperature is above said lower critical solution temperature. The emulsions are able to offer the controlled release without burst effect and afterward in a near zero order manner, as well as be non-invasively monitored post-implantation. The design of entrapment of the bioactive substances in the oily phase is also beneficial to preserve the bioactivity of the environment-sensitive substances.
-
Citations
10 Claims
-
1. A temperature-sensitive thermogelling emulsion delivery system, comprising:
-
a biodegradable temperature-sensitive aqueous phase polymer solution;
at least one bioactive substance, and a pharmaceutically acceptable oil phase carrier, said oil carrier embeds said bioactive substance;
wherein said oil phase carrier and said temperature-sensitive polymer solution are mixed mutually to form an emulsion, which is a liquid while at a temperature below a lower critical solution temperature (LCST) and transforms into a gel while the temperature of the emulsion is above said lower critical solution temperature (LCST). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
Specification