Growth of large patterned arrays of neurons on CCD chips using plasma deposition methods
First Claim
1. A neuron chip platform, comprising a charge coupled detector array device (CCD), a thin protective film over the CCD, a thin patterned film applied to the protective film to promote neuron growth, and an insulator material for insulating CCD electronics from a neuron culture.
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Abstract
Neuroelectronic devices are disclosed which use charge-coupled detector array devices to stimulate, monitor and record neural network activity and response. The method and apparatus described herein uses vacuum-arc-plasma based methods of surface modification as a tool for forming large patterned neuronal arrays on substrates. The basic device features a charge coupled detector device array (CCD) having a thin protective film over the CCD, a thin patterned film to promote neuron growth, and an insulator. Methods for stimulating and monitoring stimulated and spontaneous electrical activity in individual neurons of the array can be carried out by the apparatus described.
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Citations
20 Claims
- 1. A neuron chip platform, comprising a charge coupled detector array device (CCD), a thin protective film over the CCD, a thin patterned film applied to the protective film to promote neuron growth, and an insulator material for insulating CCD electronics from a neuron culture.
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14. A cell potential measurement apparatus comprising
a. a neuron chip platform comprising a charge coupled detector device array (CCD), a thin protective film over the CCD, a thin patterned film to promote neuron growth, and an insulator; -
b. an electrical connection means connected to the neuron chip platform;
c. an illumination source;
d. a stimulation signal supply means to be connected to the electrical connection means of the neuron chip platform for providing electrical stimulation to the cells; and
e. a signal or image processing means to be connected to the electrical connection means of the neuron chip platform for processing an output signal or image arising from electrical physiological activities of the cells. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification