Tissue reactive compounds and compositions and uses thereof
First Claim
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1. A composition comprising a synthetic polymer and a drug, the polymer comprising multiple activated groups.
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Accused Products
Abstract
A composition comprising a synthetic polymer, optionally in the presence of a drug, where the polymer comprises multiple activated groups. The multiple activated groups are reactive with functionality present on animal tissue, so that upon administration of the polymer to the tissue, the polymer binds to the tissue. Alternatively, the multiple activated groups are reactive with functionality present on a non-living surface, where the polymer binds to this surface to, e.g., increase the lubricity of the surface. When drug is present in the composition, the drug is then delivered to the site of polymer attachment.
283 Citations
240 Claims
- 1. A composition comprising a synthetic polymer and a drug, the polymer comprising multiple activated groups.
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154. A method of affecting biological processes in vivo comprising:
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a) selecting an in vivo biological tissue comprising functional groups X;
b) providing a composition comprising a synthetic polymer and a drug, the polymer comprising multiple activated groups Y, where Y is reactive with X;
c) contacting the tissue of step a) with the composition of step b) under conditions where i) X reacts with Y and ii) biological processes in the vicinity of the tissue are affected by the drug. - View Dependent Claims (155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172)
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173. A method comprising:
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a) contacting tissue in vivo with a synthetic polymer comprising multiple activated groups, where the activated groups are tissue-reactive;
b) reacting the synthetic polymer with the tissue so as to covalently adhere the synthetic polymer to the tissue. - View Dependent Claims (174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184)
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185. A method comprising:
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a) contacting a non-living surface with a synthetic polymer comprising multiple activated groups, where the activated groups are tissue-reactive;
b) reacting the synthetic polymer with the surface so as to covalently adhere the synthetic polymer to the surface. - View Dependent Claims (186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196)
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197. A method for preparing a reactive composition, the method comprising:
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a) providing a synthetic polymer comprising multiple activated groups;
b) combining the synthetic polymer with a buffer having a pH of less than 6 to form a homogeneous solution; and
c) raising the pH of the homogeneous solution to a pH of more than about 7.8, thereby rendering the synthethic polymer reactive. - View Dependent Claims (198, 199, 200, 201, 202, 203)
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204. A method of adhering a synthetic polymer to in vivo tissue, the method comprising:
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a) providing a synthetic polymer comprising multiple activated groups;
b) combining the synthetic polymer with a buffer having a pH of less than 6 to form a homogeneous solution;
c) raising the pH of the homogeneous solution to a pH of more than about 7.8, thereby rendering the synthethic polymer reactive; and
d) contacting the reactive synthetic polymer with in vivo tissue. - View Dependent Claims (205, 206, 207, 208, 209, 210, 211, 212)
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213. A composition comprising:
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a) a synthetic polymer comprising multiple activated groups; and
b) an aqueous buffer;
wherein the composition is a homogeneous solution having a pH of less than 6. - View Dependent Claims (215, 216, 217, 218, 219, 220, 221, 222, 223, 224)
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214. A composition comprising:
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a) a synthetic polymer comprising multiple activated groups; and
b) an aqueous buffer;
wherein the composition is a homogeneous solution having a pH of greater than about 7.8.
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225. A method of coating a device comprising:
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(a) applying a multifunctional hydroxysuccinimidyl PEG derivative to the surface of the device; and
(b) allowing the derivative to react with functional groups on the device surface. - View Dependent Claims (226, 227, 228, 229, 230, 231, 232)
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- 233. A method of reducing surgical adhesions comprising applying a multifunctional hydroxysuccinimidyl PEG derivative to a tissue surface.
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239. A method of reducing surgical adhesions comprising applying a tissue reactive composition consisting essentially of a multifunctional hydroxysuccinimidyl PEG derivative to a tissue surface.
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240. A method of reducing surgical adhesions comprising applying a tissue reactive composition consisting of a multifunctional hydroxysuccinimidyl PEG derivative to a tissue surface.
Specification