Gentle-acting skin-disinfectants and hydroalcoholic gel formulations

• US 20040219227A1
• Filed: 02/25/2004
• Published: 11/04/2004
• Est. Priority Date: 10/23/2001
• Status: Abandoned Application

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta, Gaonkar, Trupti A.
• Application Number:
  US10/786,681
• Publication Number:
  US 20040219227A1
• Time in Patent Office: Days
• US Class Current: 424/641
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 31/79 Polymers of vinyl pyrrolidone
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations

Abstract

Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C. This skin-friendly hydroalcoholic gel composition, which can be further combined with silicone polymer, emollient solvent, thickening agent and antimicrobial agent, enhances rapid and long-term antimicrobial efficacy.

Claims

1. An antimicrobial composition comprising octoxyglycerin, a quaternary ammonium compound, an antimicrobial agent selected from the group consisting of a biguanide compound, triclosan, phenoxyethanol, an iodine compound and parachlorometaxylenol, and a zinc compound selected from the group consisting of zinc gluconate, zinc oxide, zinc acetate, zinc stearate and zinc salicylate, wherein the zinc compound comprises between 0.2 and 7 percent.

2. An antimicrobial composition comprising between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.05 and 0.2 percent of benzalkonium chloride, between 0.5 and 4 percent of chlorhexidine digluconate, and a zinc compound selected from the group consisting of zinc gluconate, zinc oxide, zinc stearate and zinc salicylate, wherein the zinc compound comprises between 0.2 and 7 percent.