Sensor system for saccharides
First Claim
1. An analytical system for detecting a saccharide comprising:
- a) a sample known to contain or suspected of containing a saccharide;
b) one or more than one solid substrate, the solid substrate having attached thereto one or more than one saccharide sensor having the formula;
wherein;
Z is selected from the group consisting of hydrogen, alkyl groups, and aryl groups;
Bd1 and Bd2 are independently selected binding groups;
N is a nitrogen atom;
Sp is an aliphatic spacer;
An is an anchor group for attaching the sensor to the solid substrate;
S is a solid substrate; and
n=1 or 2, m=1 or 2, y=1 or 2, and x is an integer; and
c) means for detecting at least one of saccharide that is bound to the sensor or saccharide that is not bound to the sensor.
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Accused Products
Abstract
An analytical system for detecting a saccharide is provided. The analytical system includes a saccharide sensor attached to a solid substrate and having the formula:
Where Z is selected from the group consisting of hydrogen, alkyl groups, an aryl; N is a nitrogen atom; Bd1 and Bd2 are independently selected binding groups, wherein the binding groups are capable of binding an saccharide; Sp is a spacer; An is an anchor group for attaching the sensor to solid substrate; S is the solid substrate, including a bead; and n=1 or 2, m=1 or 2, y=1 or 2, and p is an integer. In one embodiment the saccharide sensor preferentially detects glucose. The invention further provides beads having the saccharide sensor attached thereto and methods of detecting glucose using the system.
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Citations
20 Claims
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1. An analytical system for detecting a saccharide comprising:
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a) a sample known to contain or suspected of containing a saccharide;
b) one or more than one solid substrate, the solid substrate having attached thereto one or more than one saccharide sensor having the formula;
wherein;
Z is selected from the group consisting of hydrogen, alkyl groups, and aryl groups;
Bd1 and Bd2 are independently selected binding groups;
N is a nitrogen atom;
Sp is an aliphatic spacer;
An is an anchor group for attaching the sensor to the solid substrate;
S is a solid substrate; and
n=1 or 2, m=1 or 2, y=1 or 2, and x is an integer; and
c) means for detecting at least one of saccharide that is bound to the sensor or saccharide that is not bound to the sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 18, 19, 20)
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- 16. A saccharide sensing bead, the bead having a saccharide sensor attached to it having the formula:
Specification