Methods and device for non-invasive analyte measurement
First Claim
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1. A method comprising the steps:
- a. exposing a body surface of a subject to mid-infrared radiation;
b. detecting mid-infrared radiation reflected from said body surface; and
, c. determining a radiation signature of said reflected mid-infrared radiation to determine an analyte concentration in a tissue of said subject.
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Abstract
The present invention is related to optical non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject'"'"'s body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods a body surface of the subject, such as the subject'"'"'s eye, with radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.
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Citations
36 Claims
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1. A method comprising the steps:
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a. exposing a body surface of a subject to mid-infrared radiation;
b. detecting mid-infrared radiation reflected from said body surface; and
,c. determining a radiation signature of said reflected mid-infrared radiation to determine an analyte concentration in a tissue of said subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An instrument comprising:
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a. a radiation source capable of generating mid-infrared radiation;
b. a mid-infrared radiation wavelength detector for detecting said generated mid-infrared radiation reflected from a surface of a subject'"'"'s body; and
,c. a display for alphanumeric or audio representations of an analyte concentration in a tissue of said subject. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 35, 36)
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23. An instrument comprising:
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a. a radiation source of mid-infrared radiation within the range of about 2.5 to about 25.0 microns; and
b. a mid-infrared radiation detector for detecting said mid-infrared radiation transmitted through a tissue of a subject within a wavelength range of between about 8.0 to about 11.0 microns. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification