System and method operating microreservoirs delivering medication in coordination with a pump delivering diluent

• US 20040220531A1
• Filed: 05/01/2003
• Published: 11/04/2004
• Est. Priority Date: 05/01/2003
• Status: Abandoned Application

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Bonderud, David L., Bui, Tuan S., Jacobson, James D.
• Application Number:
  US10/427,314
• Publication Number:
  US 20040220531A1
• Time in Patent Office: Days
• US Class Current: 604/246
• CPC Class Codes: A61M 5/1409 in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems needle sets A61M5/162
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407

Abstract

A system and method for delivering to a patient a medication including an active ingredient in coordination with a diluent according to a prescribed dosage. A plurality of microreservoirs are part of an integrated chip within a container. Each microreservoir has an the active ingredient therein and a seal associated therewith for selectively sealing the microreservoir. A supply system supplies the diluent through the container and over the plurality of microreservoirs to the patient. A controller (1) selectively activates the diluent supply system as a function of the selective opening of one or more of the plurality of microreservoirs according to the prescribed dosage or (2) selectively opens one or more of the plurality of microreservoirs as a function of the selective is activation of the diluent supply system according to the prescribed dosage.

Claims

1. A system for delivering to a patient a medication including an active ingredient coordinated with the delivery of a diluent according to a prescribed dosage, said system comprising:

a plurality of microreservoirs, each said microreservoir having the active ingredient therein and each said microreservoir having a seal associated therewith for selectively sealing each said microreservoir;

a diluent supply system for supplying the diluent over the plurality of microreservoirs to the patient; and

a controller for (1) selectively activating the diluent supply system as a function of the selective opening of one or more of the plurality of microreservoirs according to the prescribed dosage or (2) selectively opening one or more of the plurality of microreservoirs as a function of the selective activation of the diluent supply system according to the prescribed dosage.

2. The system of claim 1 wherein the diluent supply system comprises a pump for pumping the diluent, and wherein the controller comprises a pump controller for controlling operation of the pump and for individually addressing each of the plurality of microreservoirs via an electrode connected to the seal thereof to selectively open each of the plurality of microreservoirs.

3. The system of claim 2 wherein the microreservoirs are on a substrate of an integrated chip having a plurality of electrodes, each of the electrodes connected one of the seals of the microreservoirs.

4. The system of claim 2 wherein the pump is located between a source of the diluent and the plurality of microreservoirs.

5. The system of claim 4 wherein the electrodes are surface electrodes on the surface of the substrate.

6. The system of claim 2 wherein the pump is located between the plurality of microreservoirs and the patient.

7. The system of claim 2 wherein the pump controller applies an electric current to the electrode to selectively open its associated microreservoir.

8. The system of claim 7 wherein the seal for each microreservoir includes a vaporizable metallic layer connected the electrode for each microreservoir, and wherein each layer vaporizes and opens its associated microreservoir in response to the electric current applied to its electrode.

9. The system of claim 8 wherein the layer is a fuse which breaks in response to the electric current applied to its electrode.

10. The system of claim 9 further comprising a common ground electrode connected to each of the fuses.

11. The system of claim 2 wherein the controller has an input device for receiving instructions from an operator indicating an amount of the dosage and a period of time over which the dosage is to be delivered and wherein the controller selectively opens one or more of the plurality of the microreservoirs as a function of the amount of the dosage and the period of time as indicated by the instructions.

12. The system of claim 11 wherein the pump controller controls the operation of the pump as a function of the amount of the dosage and the period of time as indicated by the instructions.

13. The system of claim 12 wherein the pump controller selectively operates the pump only during periods when the medication is to be delivered.

14. The system of claim 12 wherein the pump controller selectively operates the pump according to at least one of the following:

(1) the controller is programmed to turn on the pump for a specified period of time before and after reservoir openings to ensure delivery;

(2) the controller is programmed to switch between a very low KVO (keep vein open) infusion rate and a higher rate; and

(3) the controller instructs the pump to provide a pulsatile delivery modality during reservoir opening in order to introduce increased mixing of the active ingredient and the diluent by providing turbulence.

15. The system of claim 1 wherein the controller selectively activates the diluent supply system as a function of the selective opening of one or more of the plurality of microreservoirs according to the prescribed dosage.

16. The system of claim 1 wherein the controller selectively opens one or more of the plurality of microreservoirs as a function of the selective activation of the diluent supply system according to the prescribed dosage.

17. The system of claim 1 wherein the controller selectively activates the diluent supply system as a function of the selective opening of one or more of the plurality of microreservoirs according to the prescribed dosage and selectively opens one or more of the plurality of microreservoirs as a function of the selective activation of the diluent supply system according to the prescribed dosage.

18. The system of claim 1 wherein the diluent supply system comprises variable rate diluent delivery system responsive to the controller for supplying the diluent at a rate as indicated by the controller.

19. The system of claim 1 wherein the controller has an input device for receiving instructions from an operator indicating an amount of the dosage and a period of time over which the dosage is to be delivered and wherein the controller selectively opens one or more of the plurality of the microreservoirs as a function of the amount of the dosage and the period of time as indicated by the instructions.

20. The system of claim 1 further comprising an electrode connected to each seal of each microreservoir and wherein the controller has a plurality of outputs, one connected to each of the electrodes for providing a signal on the electrode which selectively breaks the seal connected to the electrode to open the microreservoir associated with the seal.

21. The system of claim 1 for delivering to the patient a second medication including a second active ingredient in combination with the diluent according to a second prescribed dosage wherein a first plurality of the microreservoirs contain the first active ingredient and a second plurality of the microreservoirs contain the second active ingredient and wherein the controller selectively opens the first plurality of the microreservoirs via the seals therefor as a function of the first prescribed dosage and, selectively opens the second plurality of the microreservoirs via the seals therefor as a function of the second prescribed dosage.

22. The system of claim 1 for delivering to the patient a second medication including a second active ingredient in combination with the diluent according to a second prescribed dosage further comprising:

a second plurality of second microreservoirs, each said second microreservoir having the second active ingredient therein and having a seal therewith for selectively sealing it; and

wherein the second plurality of second microreservoirs is in series with the first plurality such that the supply system sequentially supplies the diluent over the first plurality of microreservoirs and then over the second plurality of microreservoirs; and

the controller selectively activates the supply system for supplying the diluent over the plurality of first and second plurality of microreservoirs and selectively opens one or more of the second plurality of microreservoirs by breaking its seal as a function of the second prescribed dosage.

23. The system of claim 22 wherein the controller opens the second plurality of microreservoirs substantially simultaneously with the opening of the first plurality of microreservoirs so that the first and second medications are substantially simultaneously delivered.

24. The system of claim 23 wherein the controller opens the second plurality of microreservoirs substantially sequentially after the opening of the first plurality of microreservoirs so that the second medication is substantially delivered via the diluent supply system after the first medication is delivered via the diluent supply system.

25. The system of claim 24 wherein the diluent supply system has an infusion line and wherein both the first medication and second medication are delivered over the infusion line.

26. The system of claim 25 wherein the first medication is incompatible with the second medication.

27. The system of claim 1 wherein the controller is connected to the seals via a wireless link including a transmitter transmitting signals in response to the controller and a receiver receiving the transmitted signals and connected to the electrodes of the microreservoirs for activating the seals.

28. The system of claim 1 further comprising a container having an inlet and an outlet wherein the plurality of microreservoirs are located within the container, the inlet connected to a diluent source for receiving the diluent and the outlet adapted to be connected to the patient to which the medication is to be delivered.

29. The system of claim 1 wherein the diluent supply system comprises an infusion pump.

30. The system of claim 1 wherein the diluent supply system comprises a syringe pump.

31. The system of claim 1 wherein the diluent supply system comprises a variable rate pump.

32. The system of claim 1 wherein the microreservoirs are integrated with diluent supply system.

33. A method for delivering to a patient a medication including an active ingredient coordinated with the delivery of a diluent according to a prescribed dosage, said method comprising:

selectively supplying a diluent over a plurality of microreservoirs to the patient as a function of the selective opening of one or more of the plurality of microreservoirs according to the prescribed dosage or

selectively opening one or more of the plurality of microreservoirs as a function of the selective supply of the diluent according to the prescribed dosage.

34. The method of claim 33 further comprising a pump for pumping the diluent, and a pump controller for controlling operation of the pump and for individually addressing each of the plurality of microreservoirs via an electrode connected to the seal thereof to selectively open each of the plurality of microreservoirs.

35. The method of claim 34 wherein the pump is located between a source of the diluent and the plurality of microreservoirs.

36. The method of claim 34 wherein the pump is located between the plurality of microreservoirs and the patient.

37. The method of claim 34 wherein the controller has an input device for receiving instructions from an operator indicating an amount of the dosage and a period of time over which the dosage is to be delivered and wherein the controller selectively opens one or more of the plurality of the microreservoirs as a function of the amount of the dosage and the period of time as indicated by the instructions.

38. The method of claim 33 comprising selectively activating the diluent supply method as a function of the selective opening of one or more of the plurality of microreservoirs according to the prescribed dosage.

39. The method of claim 33 comprising selectively opening one or more of the plurality of microreservoirs as a function of the selective activation of the diluent supply method according to the prescribed dosage.

40. The method of claim 33 comprising selectively activating the diluent supply method as a function of the selective opening of one or more of the plurality of microreservoirs according to the prescribed dosage and selectively opening one or more of the plurality of microreservoirs as a function of the selective activation of the diluent supply method according to the prescribed dosage.

41. The method of claim 33 comprising varying a delivery rate of the diluent as a function of the amount of the dosage and/or varying a period of time during which the diluent is delivered as a function of the amount of the dosage and/or selectively opening one or more of the plurality of the microreservoirs as a function of the amount of the dosage.

42. The method of claim 33 comprising delivering to the patient a second medication including a second active ingredient in combination with the diluent according to a second prescribed dosage wherein a first plurality of the microreservoirs contain the first active ingredient and a second plurality of the microreservoirs contain the second active ingredient and further comprising selectively opening the first plurality of the microreservoirs as a function of the first prescribed dosage and, selectively opens the second plurality of the microreservoirs as a function of the second prescribed dosage.