Reduction of inflammatory mass with spinal catheters
First Claim
1. An method for preventing inflammatory mass formation associated with continuous intrathecal infusion of a first solution comprising a first drug through a first infusion section of a catheter into a patient'"'"'s spinal canal at a first vertebral level, wherein the first drug has a local concentration over time at the first vertebral level in the patient'"'"'s spinal canal, and wherein the first infusion section of the catheter has a first length, the method comprising:
- reducing the local concentration of the first drug over time at the first vertebral level in the patient'"'"'s spinal canal relative to the first drug infused continuously through the first infusion section of a catheter intrathecally into a patient'"'"'s spinal canal at the first vertebral level, wherein reducing the local concentration over time comprises one or more of;
replacing continuous infusion of the first drug with intermittent bolus infusion of the first drug;
altering the density of a solution comprising the first drug;
replacing the first drug with a second drug;
changing the concentration of the first drug in a solution comprising the first drug; and
changing the vertebral location where the first drug is delivered.
1 Assignment
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Accused Products
Abstract
Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc. Methods for treating diseases, including pain and spasticity are also discussed, as well as methods for screening patients and optimizing therapies. In addition, methods for delivering a drug to a brain through a spinal canal are described.
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Citations
30 Claims
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1. An method for preventing inflammatory mass formation associated with continuous intrathecal infusion of a first solution comprising a first drug through a first infusion section of a catheter into a patient'"'"'s spinal canal at a first vertebral level, wherein the first drug has a local concentration over time at the first vertebral level in the patient'"'"'s spinal canal, and wherein the first infusion section of the catheter has a first length, the method comprising:
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reducing the local concentration of the first drug over time at the first vertebral level in the patient'"'"'s spinal canal relative to the first drug infused continuously through the first infusion section of a catheter intrathecally into a patient'"'"'s spinal canal at the first vertebral level, wherein reducing the local concentration over time comprises one or more of;
replacing continuous infusion of the first drug with intermittent bolus infusion of the first drug;
altering the density of a solution comprising the first drug;
replacing the first drug with a second drug;
changing the concentration of the first drug in a solution comprising the first drug; and
changing the vertebral location where the first drug is delivered. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification