Embolism protection devices

• US 20040220611A1
• Filed: 03/22/2004
• Published: 11/04/2004
• Est. Priority Date: 08/01/2002
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medcity Medical Innovations Incorporated
• Inventors: Ogle, Matthew F.
• Granted Patent: US 8,123,775 B2
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12027 Type of occlusion A61B17/12113 takes precedence
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12168 having a mesh structure A61B17/1214 takes precedence
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61F 2/01 Filters implantable into blood vessels
• CPC Class Codes: A61F 2002/016 made from wire-like elements
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2230/0091 helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Abstract

Embolism protection devices can be formed with a biocompatible expandable polymer that can expand upon release within a patient'"'"'s vessel. Upon release, the structure can be configured to filter flow through the vessel. The material of the embolism protection devices can release one or more biologically active agents, such as a thrombolitic agent, including, for example, tPA. Alternatively or additionally, the embolism protection device can be connected to a tether that elutes one or more biologically active agents.

Claims

1. An embolism protection device comprising a plurality of fibers having surface capillaries, wherein the fibers are bound within a structure and have a deployed configuration that fills the lumen of a vessel having a diameter corresponding to that of a human vessel.

2. The embolism protection device of claim 1 wherein fibers comprise a hydrophilic polymer.

3. The embolism protection device of claim 1 wherein the fibers comprise polyester.

4. The embolism protection device of claim 1 wherein the fibers comprise a bioresorbable polymer.

5. The embolism protection device of claim 1 wherein the fibers are within a fabric.

6. The embolism protection device of claim 1 wherein the fibers are curled.

7. The embolism protection device of claim 1 wherein the fibers have a curled configuration at body temperature.

8. The embolism protection device of claim 1 wherein the fibers are in a bundle.

9. The embolism protection device of claim 1 wherein the fibers are grafted with a second polymer.

10. The embolism protection device of claim 9 wherein the second polymer is a hydrogel.

11. The embolism protection device of claim 1 wherein the structure within the vessel has an effective pore size to trap a majority of emboli with a diameter larger than 0.2 mm while a majority of particulates with a diameter smaller than 0.001 mm pass.

12. The embolism protection device of claim 1 further comprising a biocompatible adhesive.

13. The embolism protection device of claim 1 further comprising a tether.

14. A method for trapping emboli, the method comprising placing an embolism protection device of claim 1 within a patient'"'"'s vessel.

15. A system for trapping emboli comprising a delivery tool comprising a tether and an embolism protection device attached to the tether and wherein the embolism protection device comprises a fiber with surface capillaries with a size suitable for placement within a human vessel.

16. The system of claim 15 wherein the tether is a guidewire.

17. The system of claim 15 wherein the delivery tool comprises a cannula through which the embolism protection device can be delivered.

18. The system of claim 15 wherein the fibers comprise a polyester.

19. The system of claim 15 wherein the embolism protection device is attached to the tether with an adhesive.

20. A method for trapping emboli, the method comprising placing a fiber within a patient'"'"'s vessel wherein the fibers have surface capillaries.

21. The method of claim 20 wherein a plurality of fibers with surface capillaries are placed within the patient'"'"'s vessel.

22. The method of claim 21 wherein the plurality of fibers are in a bundle.

23. The method of claim 20 wherein the placing of the fiber is performed with a delivery tool that associates with the fiber.

24. The method of claim 23 wherein the delivery tool holds the fiber in a configuration for passage through a sheath for deployment of the fiber within a vessel.

25. The method of claim 24 wherein a plurality of fibers are deployed and the plurality of fibers fill the lumen of the vessel with an effective pore size to trap a selected range of emboli.

26. The method of claim 25 wherein the delivery tool comprises a guidewire.

27. The method of claim 20 wherein the fiber is curled at body temperature.