Thermal treatment of a drug eluting implantable medical device
First Claim
1. A method of manufacturing a drug eluting implantable medical device, comprising exposing a dry coating on the device to a temperature greater than ambient temperature for a duration of time, the dry coating comprising a polymer, an active agent, and less than about 2% residual fluid content (w/w), wherein the duration of exposure is sufficient to decrease the release rate of the active agent from the coating after the coating has been implanted into a biological lumen.
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Accused Products
Abstract
A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition which can result in reduction of the rate of release of an active agent from the coating subsequent to the implantation of the device.
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Citations
82 Claims
- 1. A method of manufacturing a drug eluting implantable medical device, comprising exposing a dry coating on the device to a temperature greater than ambient temperature for a duration of time, the dry coating comprising a polymer, an active agent, and less than about 2% residual fluid content (w/w), wherein the duration of exposure is sufficient to decrease the release rate of the active agent from the coating after the coating has been implanted into a biological lumen.
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13. A method of manufacturing a stent coating, comprising:
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applying a composition to a stent, the composition including a polymer and a solvent;
allowing the solvent to evaporate to form a coating; and
exposing the coating to a temperature equal to or greater than the glass transition temperature of the polymer for a duration of time. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method of manufacturing a drug eluting stent, comprising:
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applying a composition to a stent, the composition including a semicrystalline polymer, an active agent and a solvent;
allowing the solvent to evaporate to form a dry coating, the dry coating comprising less than about 2% residual fluid content (w/w); and
exposing the dry coating to the crystallization temperature of the polymer for a duration of time. - View Dependent Claims (37, 38)
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39. A method of manufacturing a drug eluting stent, comprising:
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forming a dry polymeric coating on a stent having less than about 2% residual fluid content (w/w), the dry polymeric coating comprising a reservoir layer including a polymer and an active agent, and a barrier layer including a polymer covering a portion of the reservoir layer; and
exposing the polymer included in the barrier layer to a temperature equal to or greater than the glass transition of the polymer. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A method of manufacturing a drug eluting stent, comprising:
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forming a polymeric coating on a stent, the polymeric coating comprising a reservoir layer including a semicrystalline polymer and an active agent; and
exposing the polymer included in the reservoir layer to the crystallization temperature of the polymer. - View Dependent Claims (50, 51)
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52. A method of manufacturing a drug eluting stent, comprising:
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forming a polymeric coating on a stent, the polymeric coating comprising a reservoir layer including a polymer and an active agent, and a barrier layer including a semicrystalline polymer covering a portion of the reservoir layer; and
exposing the polymer included in the barrier layer to the crystallization temperature of the polymer. - View Dependent Claims (53, 54, 55, 56, 57, 58)
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59. A method of manufacturing a stent coating, comprising:
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applying a composition to a stent, the composition including a polymer and a solvent;
allowing the solvent to evaporate to form a coating; and
exposing the coating to a temperature sufficient to increase the crystallinity of the polymer in at least a portion of the coating. - View Dependent Claims (60, 61, 62, 63)
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64. A method of manufacturing a drug eluting stent, comprising:
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forming a polymeric coating including an active agent on a stent strut, the coating having a first segment and a second segment as measured along the length of the stent; and
exposing the first and second segments to different thermal conditions such that the active agent has a higher diffusion rate through the polymer in the first segment of the coating as compared to the polymer in the second segment of the coating. - View Dependent Claims (65, 66, 67, 68, 69)
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- 70. A stent comprising a radially expandable body and a coating covering at least a portion of the body, the coating comprising a polymer and an active agent, wherein the polymer includes at least two degrees of crystallinity.
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75. A method of coating an implantable medical device, comprising:
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applying a composition to an implantable medical device, the composition comprising a polymer dissolved in a solvent; and
heating the composition to a temperature equal to or greater than the glass transition temperature of the polymer. - View Dependent Claims (76, 77, 78, 79, 80, 81, 82)
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Specification