Immunoneutral silk-fiber-based medical devices
First Claim
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1. A fabric comprising:
- a yarn, said yarn comprising one or more sericin-extracted fibroin fibers, said fibers being biocompatible and non-randomly organized, wherein said yarn promotes ingrowth of cells around said fibroin fibers and is biodegradable.
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Abstract
Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
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Citations
49 Claims
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1. A fabric comprising:
- a yarn, said yarn comprising one or more sericin-extracted fibroin fibers, said fibers being biocompatible and non-randomly organized, wherein said yarn promotes ingrowth of cells around said fibroin fibers and is biodegradable.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for forming a fabric comprising:
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a. aligning fibroin fibers in parallel or intertwined with other fibroin fibers to form a yarn, b. substantially removing sericin from the fibroin fibers without substantially altering the native structure of fibroin in the fibers, c. and organizing a plurality of yarns to form a fabric. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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Specification