System and method for iontophoretic transdermal delivery of one or more therapeutic agents

• US 20040225253A1
• Filed: 06/10/2004
• Published: 11/11/2004
• Est. Priority Date: 07/29/2002
• Status: Abandoned Application

• Current Assignee: Eemso Incorporated
• Original Assignee: Eemso Incorporated
• Inventors: Shevlin, Daniel P.
• Application Number:
  US10/865,343
• Publication Number:
  US 20040225253A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

In one embodiment, a system for iontophoretic transdermal delivery of one or more therapeutic agents into a user'"'"'s skin includes a first reservoir for containing one or more therapeutic agents, a second reservoir for containing one or more therapeutic agents, and a self-contained power source for generating electric current. The power source includes a first terminal and a second terminal. The system also includes a first electrode for electrically coupling the first terminal of the power source to the first reservoir. The first electrode is operable to conduct electric current between the power source and the first reservoir to ionize the one or more therapeutic agents contained within the first reservoir for iontophoretic transdermal delivery into the user'"'"'s skin. The system also includes a second electrode for electrically coupling the second terminal of the power source to the second reservoir. The second electrode is operable to conduct electric current between the power source and the second reservoir to ionize the one or more therapeutic agents contained within the second reservoir for iontophoretic transdermal delivery into the user'"'"'s skin.

Claims

1. A system for iontophoretic transdermal delivery of one or more therapeutic agents into a user'"'"'s skin, comprising:

a first reservoir for containing one or more therapeutic agents;

a second reservoir for containing one or more therapeutic agents;

a self-contained power source for generating electric current, the power source comprising a first terminal and a second terminal;

a first electrode for electrically coupling the first terminal of the power source to the first reservoir, the first electrode operable to conduct electric current between the power source and the first reservoir to promote iontophoretic transdermal delivery of the one or more therapeutic agents contained within the first reservoir into the user'"'"'s skin; and

a second electrode for electrically coupling the second terminal of the power source to the second reservoir, the second electrode operable to conduct electric current between the power source and the second reservoir to promote iontophoretic transdermal delivery of the one or more therapeutic agents contained within the second reservoir into the user'"'"'s skin;

the self-contained power source, the first electrode, and the second electrode together comprising a flexible circuit element adapted to be selectively folded or unfolded such that in a folded configuration a first portion of the circuit element at least partially overlays a second portion of the circuit element and in an unfolded configuration the first portion of the circuit element does not overlay the second portion of the circuit element.

2. The system of claim 1, wherein the first reservoir is associated with a positive terminal of the power source and the second reservoir is associated with a negative terminal of the power source.

3. The system of claim 1, wherein the self-contained power source is a battery.

4. The system of claim 3, wherein the battery is a 1.55 volt battery.

7. The system of claim 1, wherein the power source is insulated in a protective covering.

8. The system of claim 7, wherein the protective covering is made from a polymer or gel-like substance.

9. The system of claim 1, wherein the first electrode, the second electrode, and the power source are disposed between at least one layer of insulating material to protect the user'"'"'s skin.

29. The system of claim 1, wherein the electric currents ionize the one or more therapeutic agents contained within the reservoirs for iontophoretic transdermal delivery into the user'"'"'s skin.

5. (Canceled)

6. The system of claim 5, further comprising a hidden pocket adapted to house at least a portion of the flexible circuit element when the flexible circuit element is in the folded configuration.

10. A method for manufacturing a system for iontophoretic transdermal delivery of one or more therapeutic agents into a user'"'"'s skin, comprising:

providing a first reservoir for containing one or more therapeutic agents;

providing a second reservoir for containing one or more therapeutic agents;

providing a self-contained power source for generating electric current, the power source comprising a first terminal and a second terminal;

providing a first electrode for electrically coupling the first terminal of the power source to the first reservoir, the first electrode operable to conduct electric current between the power source and the first reservoir to promote iontophoretic transdermal delivery of the one or more therapeutic agents contained within the first reservoir into the user'"'"'s skin; and

providing a second electrode for electrically coupling the second terminal of the power source to the second reservoir, the second electrode operable to conduct electric current between the power source and the second reservoir to promote iontophoretic transdermal delivery of the one or more therapeutic agents contained within the second reservoir into the user'"'"'s skin;

the self-contained power source, the first electrode, and the second electrode together comprising a flexible circuit element adapted to be selectively folded or unfolded such that in a folded configuration a first portion of the circuit element at least partially overlays a second portion of the circuit element and in an unfolded configuration the first portion of the circuit element does not overlay the second portion of the circuit element.

11. The method of claim 10, wherein the first reservoir is associated with a positive terminal of the power source and the second reservoir is associated with a negative terminal of the power source.

12. The method of claim 10, wherein providing a self-contained power source comprises providing a battery for generating electric current.

13. The method of claim 12, wherein the battery is a 1.55 volt battery.

16. The method of claim 10, further comprising providing a protective covering to insulate the power source.

17. The method of claim 16, wherein the protective covering is made from a polymer or gel-like substance.

18. The method of claim 10, further comprising providing at least one layer of insulating material disposed about the first electrode, the second electrode, and the power source to protect the user'"'"'s skin.

30. The method of claim 10, wherein the electric currents ionize the one or more therapeutic agents contained within the reservoirs for iontophoretic transdermal delivery into the user'"'"'s skin.

14. (canceled)

15. The method of claim 14, further comprising providing a hidden pocket adapted to house at least a portion of the flexible circuit element when the flexible circuit element is in the folded configuration.

19. A method for delivering one or more therapeutic agents to a user through the user'"'"'s skin, comprising:

positioning an iontophoretic transdermal delivery system about a portion of the user'"'"'s body to receive treatment, the system comprising;

a first reservoir for containing one or more therapeutic agents;

a second reservoir for containing one or more therapeutic agents; and

a self-contained power source for generating electric current, the power source comprising a first terminal and a second terminal;

a first electrode for electrically coupling the first terminal of the power source to the first reservoir, the first electrode operable to conduct electric current between the power source and the first reservoir to promote iontophoretic transdermal delivery of the one or more therapeutic agents contained within the first reservoir into the user'"'"'s skin;

a second electrode for electrically coupling the second terminal of the power source to the second reservoir, the second electrode operable to conduct electric current between the power source and the second reservoir to promote iontophoretic transdermal delivery of the one or more therapeutic agents contained within the second reservoir into the user'"'"'s skin;

the self-contained power source, the first electrode, and the second electrode together comprising a flexible circuit element adapted to be selectively folded or unfolded such that in a folded configuration a first portion of the circuit element at least partially overlays a second portion of the circuit element and in an unfolded configuration the first portion of the circuit element does not overlay the second portion of the circuit element;

applying electrical current to the therapeutic agents contained in the reservoirs using the power source; and

delivering the therapeutic agents to the user through the user'"'"'s skin in response to the electrical current.

20. The method of claim 19, wherein the first reservoir is associated with a positive terminal of the power source and the second reservoir is associated with a negative terminal of the power source.

21. The method of claim 19, wherein the self-contained power source is a battery.

22. The method of claim 21, wherein the battery is a 1.55 volt battery.

25. The method of claim 19, wherein the power source is insulated in a protective covering.

26. The method of claim 25, wherein the protective covering comprises a polymer or gel-like substance.

27. The method of claim 19, wherein the first electrode, the second electrode, and the power source are disposed between at least one layer of insulating material to protect the user'"'"'s skin.

31. The method of claim 19, wherein the electric currents ionize the one or more therapeutic agents contained within the reservoirs for iontophoretic transdermal delivery into the user'"'"'s skin.

23. (Canceled)

24. The method of claim 23, wherein the system further comprises a hidden pocket adapted to house at least a portion of the flexible circuit element when the flexible circuit element is in the folded configuration.

28. A system for iontophoretic transdermal delivery of one or more therapeutic agents into a user'"'"'s skin, comprising:

first reservoir means for containing one or more therapeutic agents;

second reservoir means for containing one or more therapeutic agents; and

self-contained power source means for generating electric current, the power source means comprising a first terminal and a second terminal;

first electrode means for electrically coupling the first terminal of the power source means to the first reservoir means, the first electrode means operable to conduct electric current between the power source means and the first reservoir means to promote iontophoretic transdermal delivery of the one or more therapeutic agents contained within the first reservoir means into the user'"'"'s skin;

second electrode means for electrically coupling the second terminal of the power source means to the second reservoir means, the second electrode means operable to conduct electric current between the power source means and the second reservoir means to ionize promote iontophoretic transdermal delivery of the one or more therapeutic agents contained within the second reservoir means into the user'"'"'s skin;

the self-contained power source means the first electrode means and the second electrode means together comprising a flexible circuit means adapted to be selectively folded or unfolded such that in a folded configuration a first portion of the circuit means at least partially overlays a second portion of the circuit means and in an unfolded configuration the first portion of the circuit means does not overlay the second portion of the circuit means.