Systems and methods for characterizing a biological condition or agent using selected gene expression profiles
First Claim
Patent Images
1. A descriptive record of a particular biological condition in a first population of cells based on a first sample of cells having the biological condition, comprising:
- a set of numerical gene expression values for a selected panel of gene loci constituents selected from either the private or public experimental record or both to be informative about the particular biological condition, each value in the set corresponding to a unique gene locus constituent in the panel of gene loci constituents, the set of values forming a first profile data set for the population of cells having the particular biological condition, wherein the gene expression value for each constituent is obtained under measurement conditions that are reproducible within 20 percent.
1 Assignment
0 Petitions
Accused Products
Abstract
Methods are provided for evaluating a biological condition of a subject using a calibrated profile data set derived from a data set having a plurality of members, each member being a quantitative measure of the amount of a subject'"'"'s RNA or protein as distinct constituents in a panel of constituents. The biological condition may be a naturally occurring physiological state or may be responsive to treatment of the subject with one or more agents. Calibrated profile data sets may be used as a descriptive record for an agent.
-
Citations
66 Claims
-
1. A descriptive record of a particular biological condition in a first population of cells based on a first sample of cells having the biological condition, comprising:
-
a set of numerical gene expression values for a selected panel of gene loci constituents selected from either the private or public experimental record or both to be informative about the particular biological condition, each value in the set corresponding to a unique gene locus constituent in the panel of gene loci constituents, the set of values forming a first profile data set for the population of cells having the particular biological condition, wherein the gene expression value for each constituent is obtained under measurement conditions that are reproducible within 20 percent. - View Dependent Claims (2)
-
-
3. A descriptive record of a particular biological condition in a first population of cells based on a first sample of cells having the biological condition, comprising:
-
a set of numerical gene expression values for a selected panel of gene loci constituents selected from either the private or public experimental record or both to be informative about the particular biological condition, each value in the set corresponding to a unique gene locus constituent in the panel of gene loci constituents, the set of values forming a first profile data set for the population of cells having the particular biological condition, wherein the gene expression value for each constituent is obtained under measurement conditions that are reproducible such that the coefficient of variation for each value is less than approximately 3 percent. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
-
Specification