Dual chamber dissolution container with passive agitation

• US 20040228769A1
• Filed: 06/22/2004
• Published: 11/18/2004
• Est. Priority Date: 05/04/2001
• Status: Abandoned Application

• Current Assignee: Carolyn Fitzgerald, Michael A. Taylor
• Original Assignee: Carolyn Fitzgerald, Michael A. Taylor
• Inventors: Taylor, Michael A., Fitzgerald, Carolyn
• Application Number:
  US10/874,630
• Publication Number:
  US 20040228769A1
• Time in Patent Office: Days
• US Class Current: 422/99
• CPC Class Codes: A61M 5/284 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/286 upon internal pressure increase, e.g. pierced or burst A61M5/283 takes precedence
• CPC Class Codes: A61M 5/31596 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: B01F 21/00 Dissolving separating by dissolving B01D; dissolving to effect cooling F25D5/00
• CPC Class Codes: B01F 33/5011 portable during use, e.g. hand-held
• CPC Class Codes: B01F 33/50112 of the syringe or cartridge type
• CPC Class Codes: B01F 35/713 comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges containers or packages per se B65D
• CPC Class Codes: B01J 19/1812 Tubular reactors
• CPC Class Codes: B01J 19/26 Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
• CPC Class Codes: B01J 8/0278 Feeding reactive fluids for solid material B01J8/0015

Abstract

A reagent dissolution device and methods of using the same, wherein the device comprises a housing (40), a diluent (25), and at least one reagent bed (35), wherein the diluent (25) and the at least one reagent bed (35) are separated by a friable barrier (50) and a flow distribution disk (100). Alternate embodiments include chambers with a plurality of reagent beds as well as chambers for the mixing of two or more liquid reagents.

Claims

1. A reagent dissolution device comprising a housing, a diluent, and at least one reagent bed, wherein the diluent and the at least one reagent bed are separated by a friable barrier and a flow distribution disk.

2. The reagent dissolution device of claim 1, further comprising a porous expansion component located between the friable barrier and the flow distribution disk.

3. The reagent dissolution device of claim 1, wherein the flow distribution disk contains a plurality of directional channels disposed at a range from 30 to 90 degrees with respect to the vertical axis of the disk.

4. The reagent dissolution device of claim 1, wherein the flow distribution disk contains a plurality of directional channels disposed at a range from 45 to 75 degrees with respect to the vertical axis of the disk.

5. The reagent dissolution device of claim 1, wherein the flow distribution disk contains a plurality of directional channels disposed at a range from 55 to 65 degrees with respect to the vertical axis of the disk.

6. The reagent dissolution device of claim 1, wherein the flow distribution disk comprises a top layer and an adjacently disposed bottom layer that form a distribution chamber.

7. The reagent dissolution device of claim 6, wherein the bottom layer is a porous plate.

8. The reagent dissolution device of claim 6, wherein the bottom layer comprises a plurality of directional channels bounded by an inlet port and an outlet port.

9. The reagent dissolution device of claim 1, further comprising a pressure-generating plunger.

10. The reagent dissolution device of claim 1, further comprising a pressure-generating spring.

11. The reagent dissolution device of claim 1, wherein the diluent comprises a first liquid reagent.

12. The reagent dissolution device of claim 11, wherein the at least one reagent bed contains a second liquid reagent.

13. The reagent dissolution device of claim 1, wherein the at lest one reagent bed comprises a dry reagent bed.

14. A method of preparing a pharmaceutically acceptable solution comprising:

providing a dissolution chamber, wherein the dissolution chamber comprises a housing, a diluent, and at least one reagent bed, wherein the diluent and the at least one reagent bed are separated by a friable barrier and a flow distribution disk;

applying sufficient pressure to the diluent such that the friable barrier is ruptured and the diluent is applied to the flow distribution disk, micro-spirals are creating in the diluent emerging from the distribution disk; and

dissolving the at least one reagent bed with the diluent such that the pharmaceutically acceptable solution is prepared.

15. The method of claim 14, wherein mixing comprises dissolving dry reagent from the at least one reagent bed.

16. The method of claim 14, wherein mixing comprises mixing the diluent with liquid reagent from the at least one reagent bed.