Methods for treating post-surgical pain by administering a nerve growth factor antagonist and compositions containing the same

• US 20040228862A1
• Filed: 10/08/2003
• Published: 11/18/2004
• Est. Priority Date: 10/08/2002
• Status: Active Grant

• Current Assignee: Rinat Neuroscience Corp. (Pfizer Inc.)
• Original Assignee: Rinat Neuroscience Corp. (Pfizer Inc.)
• Inventors: Vergara, German J., Shelton, David L.
• Granted Patent: US 7,252,822 B2
• Time in Patent Office: Days
• US Class Current: 424/145.1
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 16/22 against growth factors ; against growth regulators
• CPC Class Codes: C07K 2317/24 containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Abstract

The invention features methods and compositions for preventing or treating pain resulting from surgery or an incision by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.

Claims

1. A method for treating post-surgical pain in an individual comprising administering to the individual an effective amount of an antagonist of nerve growth factor (NGF), wherein the NGF antagonist is other than TrkA immunoadhesin.

2. The method of claim 1, wherein resting pain is suppressed or ameliorated.

3. The method of claim 1, wherein mechanically-induced pain is suppressed or ameliorated.

4. The method of claim 1, further wherein the NGF antagonist is other than an anti-NGF antibody.

5. The method of claim 1, wherein the NGF antagonist is a kinase inhibitor capable of inhibiting downstream kinase signaling associated with NGF receptor activity.

6. The method of claim 5, wherein the kinase inhibitor is K252a.

7. A kit for treating post-surgical pain comprising an NGF antagonist, and instructions for using the NGF antagonist to treat post-surgical pain, wherein the NGF antagonist is other than trkA immunoadhesin.

8. The kit of claim 7, further wherein the NGF antagonist is other than an anti-NGF antibody.