Dosage form having a saccharide matrix

• US 20040228919A1
• Filed: 02/23/2004
• Published: 11/18/2004
• Est. Priority Date: 02/28/2003
• Status: Active Grant

• Current Assignee: Alk-Abellã³ A/S (Alk Abello A/s)
• Original Assignee: Alk-Abellã³ A/S (Alk Abello A/s)
• Inventors: Houghton, Christian G., Lundegaard, Annette R.
• Granted Patent: US 8,012,505 B2
• Time in Patent Office: Days
• US Class Current: 424/484
• CPC Class Codes: A61K 2039/542 oral/gastrointestinal
• CPC Class Codes: A61K 39/35 Allergens
• CPC Class Codes: A61K 39/36 from pollen
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/19 lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: A61K 9/2018 Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
• CPC Class Codes: A61K 9/2059 Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Abstract

The present invention provides a non-compressed fast-dispersing solid dosage form suitable for oromucosal administration of a pharmaceutically active substance comprising

(a) a first matrix forming agent in the form of maltodextrin having a dextrose equivalent (DE) of between 1 and 20,

(b) a second matrix forming agent in the form of sorbitol, and

(c) the active substance.

Claims