Temperature controlled solute delivery system

• US 20040228922A1
• Filed: 02/27/2004
• Published: 11/18/2004
• Est. Priority Date: 03/31/1998
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Gehrke, Stevin H., Fisher, John P., McBride, James F.
• Granted Patent: US 7,407,671 B2
• Time in Patent Office: Days
• US Class Current: 424/488
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 2300/258 Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61L 29/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: C08L 1/00 Compositions of cellulose, modified cellulose or cellulose derivatives
• CPC Class Codes: C08L 1/26 Cellulose ethers

Abstract

A system for delivering solute to a target location within a mammalian body, the system including a medical device, a thermosensitive cellulose gel structure over the medical device, and a biologically active solute within said gel structure. The gel structure deswells and expels the biologically active solute with an increase in gel temperature. The invention includes a method of delivering solute to a target location, where the method includes the steps of providing a thermosensitive cellulose gel structure, wherein the gel structure is loaded with a solute; positioning the loaded gel structure to the target location; and increasing the temperature of the loaded gel structure.

Claims

1-17. -17. (Canceled)

18. A method of delivering solute to a target location, the method comprising the steps of:

providing a crosslinked thermosensitive cellulose ether gel structure, wherein said gel structure is loaded with a solute;

providing functional groups on said polymer material;

adding a crosslinking material to said cellulose ether gel, said crosslinking material for reacting with said functional groups and thereby capable of attaching said cellulose ether gel to a substrate;

coating said gel onto a substrate;

positioning said loaded gel structure to said target location; and

increasing the temperature of said loaded gel structure from an initial temperature to a temperature at or above the transition temperature of said gel,

wherein said substrate comprises a polymer material.

19. The method of claim 18, wherein:

said polymer material is polyethylene terephthalate;

said functional groups comprise amine groups; and

said linking material comprises divinylsulfone.

20. The method of claim 19, further comprising the step of exposing said polyethylene terephthalate to ethylenediamine to form said amine groups.

21. A method of delivering solute to a target location, the method comprising the steps of:

providing a crosslinked thermosensitive cellulose ether gel structure, wherein said gel structure is loaded with a solute;

coating said gel onto a substrate;

positioning said loaded gel structure to said target location; and

increasing the temperature of said loaded gel structure from an initial temperature to a temperature at or above the transition temperature of said gel, wherein;

said target location is located within a mammalian body;

said substrate is a medical device; and

said solute is a biologically active solute.

22. The method of claim 21, wherein

said step of increasing the temperature of said loaded gel structure is accomplished by exposing said loaded gel structure to an external liquid having a temperature greater than said initial temperature of said loaded gel structure.

23. The method of claim 21, wherein

said step of increasing the temperature of said loaded gel structure is accomplished by exposing said loaded gel structure to body temperature.

24. A method of delivering solute to a target location, the method comprising the steps of:

providing a cross linked thermosensitive cellulose ether gel structure, wherein said gel structure is loaded with a solute;

providing functional groups on said polymer material;

adding a crosslinking material to said cellulose ether gel, said crosslinking material for reacting with said functional groups and thereby capable of attaching said cellulose ether gel to a substrate;

coating said gel onto a substrate;

positioning said loaded gel structure to said target location; and

increasing the temperature of said loaded gel structure from an initial temperature below the transition temperature of said gel to a temperature at or above the transition temperature of said gel,

wherein said step of increasing the temperature of said loaded gel structure results in the deswelling of said gel and the release of said solute from said gel,

wherein said substrate comprises a polymer material.

25. The method of claim 24, wherein:

said polymer material is polyethylene terephthalate;

said functional groups comprise amine groups; and

said linking material comprises divinylsulfone.

26. The method of claim 25, further comprising the step of exposing said polyethylene terephthalate to ethylenediamine to form said amine groups.

27. A method of delivering solute to a target location, the method comprising the steps of:

providing a cross linked thermosensitive cellulose ether gel structure, wherein said gel structure is loaded with a solute;

coating said gel onto a substrate;

positioning said loaded gel structure to said target location; and

increasing the temperature of said loaded gel structure from an initial temperature below the transition temperature of said gel to a temperature at or above the transition temperature of said gel,

wherein said step of increasing the temperature of said loaded gel structure results in the deswelling of said gel and the release of said solute from said gel,

wherein;

said target location is located within a mammalian body;

said substrate is a medical device; and

said solute is a biologically active solute.

28. The method of claim 27, wherein

said step of increasing the temperature of said loaded gel structure is accomplished by exposing said loaded gel structure to an external liquid having a temperature greater than said initial temperature of said loaded gel structure.

29. The method of claim 27, wherein

said step of increasing the temperature of said loaded gel structure is accomplished by exposing said loaded gel structure to body temperature.