Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt
First Claim
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1. A method of lowering serum triglyceride levels in a patient with elevated serum triglyceride levels comprising administering about 300 mg or less of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt.
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Abstract
Methods for selectively modulating triglyceride, high-density lipoprotein, and low-density lipoprotein levels in a patient by administering a certain dose of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt are disclosed.
106 Citations
32 Claims
- 1. A method of lowering serum triglyceride levels in a patient with elevated serum triglyceride levels comprising administering about 300 mg or less of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt.
- 5. A method of raising high density lipoprotein-cholesterol levels in a patient with elevated serum triglyceride levels comprising administering about 300 mg or less of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt.
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9. A method of lowering serum triglyceride levels and raising high density lipoprotein-cholesterol levels in a patient with elevated serum triglyceride levels (defined as those ≧
- 200 mg/dL) comprising administering about 300 mg or less of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt.
- View Dependent Claims (10, 11, 12)
- 13. A method of lowering low density lipoprotein-cholesterol levels in a patient comprising administering greater than 300 mg of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt.
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17. A method of lowering serum triglyceride levels without lowering low density lipoprotein-cholesterol levels in a patient with elevated serum triglyceride levels (defined as those >
- 200 mg/dL) comprising administering about 300 mg or less of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt.
- View Dependent Claims (18, 19, 20)
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21. A method of raising high density lipoprotein-cholesterol levels without lowering low density lipoprotein-cholesterol levels in a patient with elevated serum triglyceride levels (defined as those ≧
- 200 mg/dL) comprising administering about 300 mg or less of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt.
- View Dependent Claims (22, 23, 24)
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25. A method of lowering serum triglyceride levels and raising high density lipoprotein-cholesterol levels without lowering low density lipoprotein-cholesterol levels in a patient with elevated serum triglyceride levels (defined as those ≧
- 200 mg/dL) comprising administering about 300 mg or less of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt.
- View Dependent Claims (26, 27, 28)
- 29. A method of lowering low density lipoprotein-cholesterol levels without lowering serum triglyceride levels or raising high density lipoprotein-cholesterol levels in a patient comprising administering greater than 300 mg of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt.
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Current AssigneeDiane Elaine Macdougall, Rebecca Guggemos Bakker-Arkema
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Original AssigneeDiane Elaine Macdougall, Rebecca Guggemos Bakker-Arkema
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InventorsMacDougall, Diane Elaine, Bakker-Arkema, Rebecca Guggemos
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Application NumberUS10/844,879Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current514/574CPC Class CodesA61K 31/19 Carboxylic acids, e.g. valp...
