Device and method for monitoring body fluid and electrolyte disorders
First Claim
1. A device for measuring a body-tissue water content metric as a fraction of the fat-free tissue content of a patient using optical spectrophotometry, comprising:
- a probe housing configured to be placed proximal to a tissue location which is being monitored;
light emission optics connected to said housing and configured to direct radiation at said tissue location;
light detection optics connected to said housing and configured to receive radiation from said tissue location; and
a processing device configured to process radiation from said light emission optics and said light detection optics to compute said metric wherein said metric comprises a ratio of the water content of a portion of patient'"'"'s tissue in relation to the lean or fat-free content of a portion of patient'"'"'s tissue.
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Accused Products
Abstract
Devices and methods for measuring body fluid-related metric using spectrophotometry that may be used to facilitate diagnosis and therapeutic interventions aimed at restoring body fluid balance. In one embodiment, the present invention provides a device for measuring a body-tissue water content metric as a fraction of the fat-free tissue content of a patient using optical spectrophotometry. The device includes a probe housing configured to be placed near a tissue location which is being monitored; light emission optics connected to the housing and configured to direct radiation at the tissue location; light detection optics connected to the housing and configured to receive radiation from the tissue location; and a processing device configured to process radiation from the light emission optics and the light detection optics to compute the metric where the metric includes a ratio of the water content of a portion of patient'"'"'s tissue in relation to the lean or fat-free content of a portion of patient'"'"'s tissue.
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Citations
47 Claims
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1. A device for measuring a body-tissue water content metric as a fraction of the fat-free tissue content of a patient using optical spectrophotometry, comprising:
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a probe housing configured to be placed proximal to a tissue location which is being monitored;
light emission optics connected to said housing and configured to direct radiation at said tissue location;
light detection optics connected to said housing and configured to receive radiation from said tissue location; and
a processing device configured to process radiation from said light emission optics and said light detection optics to compute said metric wherein said metric comprises a ratio of the water content of a portion of patient'"'"'s tissue in relation to the lean or fat-free content of a portion of patient'"'"'s tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A device for measuring a body-tissue metric using optical spectrophotometry, comprising:
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a probe housing configured to be placed proximal to a tissue location which is being monitored;
light emission optics connected to said housing and configured to direct radiation at said tissue location;
light detection optics connected to said housing and configured to receive radiation from said tissue location; and
a processing device configured to process radiation from said light emission optics and said light detection optics to compute said metric wherein said body tissue metric comprises a quantified measure of a ratio of a difference between the water fraction in the blood and the water fraction in the extravascular tissue over the fractional volume concentration of hemoglobin in the blood. - View Dependent Claims (29, 30, 31, 32, 33, 34)
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35. A method for measuring a body-tissue water content metric in a human tissue location as a fraction of the fat-free tissue content of a patient using optical spectrophotometry, comprising:
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placing a probe housing proximal to said tissue location;
emitting radiation at said tissue location using light emission optics configured to direct radiation at said tissue location;
detecting radiation using light detection optics configured to receive radiation from said tissue location;
processing said radiation from said light emission optics and said light detection optics;
computing said water content metric, wherein said water content metric, ƒ
wl is determined such thatpn and qm are calibration coefficients;
R(λ
) is a measure of a received radiation at a wavelength;
n=1−
N and m=1−
M represent indexes for a plurality of wavelengths which may comprise of the same or different combinations of wavelengths; and
displaying said water content metric on a display device connected to said probe housing.
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36. A method for measuring a body-tissue metric in a human tissue location using optical spectrophotometry, comprising:
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placing a probe housing proximal to said tissue location;
emitting radiation using light emission optics configured to direct radiation at said tissue location;
detecting radiation using light detection optics configured to receive radiation from said tissue location;
processing said radiation from said light emission optics and said light detection optics to compute said metric wherein said body fluid-related metric comprises a quantified measure of a ratio of a difference between the water fraction in the blood and the water fraction in the extravascular tissue over the fractional volume concentration of hemoglobin in the blood; and
displaying said metric or a quantity derived from said metric on a display device. - View Dependent Claims (37)
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38. A method of measuring a physiological parameter in a human tissue location, comprising:
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emitting radiation at said tissue location using light emission optics configured to direct radiation at said tissue location;
detecting radiation using light detection optics configured to receive radiation from said tissue location;
processing said radiation from said light emission optics and said light detection optics; and
computing said physiological parameter, wherein said parameter is determined such that it is equal to and where;
pn and qm are calibration coefficients;
R(λ
) is a measure of a received radiation at a wavelength;
n=1−
N and m=1−
M represent indexes for a plurality of wavelengths which may comprise of the same or different combinations of wavelengths. - View Dependent Claims (39, 40, 41, 42, 43)
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44. A method of assessing changes in volume and osmolarity of body fluids in a body tissue, comprising:
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emitting radiation at said tissue location using light emission optics configured to direct radiation at said tissue location;
detecting radiation using light detection optics configured to receive radiation from said tissue location;
processing said radiation from said light emission optics and said light detection optics;
determining a water balance index using said processing;
determining a tissue water concentration using said processing; and
analyzing in combination said water balance index and said tissue water concentration to assess said changes in volume and osmolarity of body fluids near said tissue location. - View Dependent Claims (45, 46, 47)
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Specification