Methods, systems, and associated implantable devices for radiation dose verification for therapies used to treat tumors
First Claim
1. A method for evaluating external beam radiation therapy delivered to a subject, comprising:
- placing at least one wireless implantable sensor in a first subject at a target location;
administering a first dose of radiation therapy into the first subject;
obtaining radiation data from the at least one wireless implantable sensor; and
calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
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Accused Products
Abstract
Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
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Citations
32 Claims
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1. A method for evaluating external beam radiation therapy delivered to a subject, comprising:
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placing at least one wireless implantable sensor in a first subject at a target location;
administering a first dose of radiation therapy into the first subject;
obtaining radiation data from the at least one wireless implantable sensor; and
calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A system for evaluating external beam radiation therapy delivered to a subject, comprising:
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at least one wireless implantable radiation sensor adapted to be placed subsurface in a subject at a target location; and
a reader operatively associated with the at least one wireless sensor, the reader configured to;
(a) wirelessly communicate with the at least one sensor;
(b) analyze radiation data telemetrically obtained from the at least one wireless implantable sensor; and
(c) calculate the radiation dose amount received by the subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to an externally administered dose of radiation to verify that a desired planned dose amount of external beam radiation is delivered to the target location. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A computer program product for evaluating external beam radiation therapy delivered to a subject, the computer program product comprising:
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a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for commencing a first wireless data transmission from an implantable wireless radiation sensor with at least one sensor element, the wireless sensor positioned in a subject at a target location corresponding to an actual or simulated depth and position of a target treatment tumor site to detect a dose of radiation received thereat; and
computer readable program code for calculating a radiation dose amount received by the subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to external beam radiation; and
computer readable program code to determine whether the calculated delivered dose corresponds to a predetermined planned dose.
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31. A method of evaluating a tumor radiation treatment, comprising the steps of:
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(a) detecting radiation delivered to a subject using at least one implantable wireless sensor positioned at a location corresponding to an actual or simulated tumor site in a subject;
(b) wirelessly transmitting the detected radiation to a receiver located external to the subject; and
(c) determining the amount of radiation delivered to the tumor site.
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32. A tumor treatment evaluation system for evaluating a radiation therapy, comprising:
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at least one implantable sensor unit configured and sized for placement at a depth and position in a subject that corresponds to a target cancerous tumor treatment site, the sensor configured to detect a therapeutic amount of radiation exposure at the target site; and
a remote receiver in wireless communication with said at least one sensor unit, said receiver configured to receive radiation data from the at least one sensor and calculate the therapeutic radiation dose detected by the sensor unit at the target site.
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Specification