Methods and devices for in-situ crosslinking of vascular tissue
First Claim
1. A method for crosslinking an extra cellular matrix layer in the vascular system of the body comprising:
- providing a vascular catheter;
delivering a crosslinking agent to the extra cellular matrix layer with the vascular catheter; and
irradiating the extra cellular matrix layer and crosslinking agent with light energy emitted from the vascular catheter.
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Abstract
A method for treating vulnerable plaque by crosslinking the fibrous cap, or collagenous extra cellular matrix layer, on the inner wall or vascular intima of the vessel. The method includes providing a vascular catheter, delivering a crosslinking agent to the extra cellular matrix layer with the vascular catheter, and irradiating the extra cellular matrix layer and crosslinking agent with light energy emitted from the vascular catheter. The crosslinking agent may be a saccharide, Riboflavin or Riboflavin-5-phosphate, or a photooxidizer. The irradiation energy is emitted from one or more LEDs mounted on the catheter. Catheter balloons are used to clear the optical path of blood so that short wavelength light can be used. The balloons may also be used to facilitate delivery of the crosslinking agent to the extra cellular matrix layer. A perfusion lumen ensures continuous blood flow during the procedure.
187 Citations
43 Claims
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1. A method for crosslinking an extra cellular matrix layer in the vascular system of the body comprising:
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providing a vascular catheter;
delivering a crosslinking agent to the extra cellular matrix layer with the vascular catheter; and
irradiating the extra cellular matrix layer and crosslinking agent with light energy emitted from the vascular catheter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for crosslinking an extra cellular matrix layer in the vascular system of the body comprising:
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delivering a saccharide to the extra cellular matrix layer; and
irradiating the extra cellular matrix layer and saccharide with light energy to crosslink the extra cellular matrix layer. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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22. A method for crosslinking an extra cellular matrix layer in the vascular system of the body comprising:
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delivering an agent selected from the group consisting of Riboflavin and Riboflavin-5-phosphate to the extra cellular matrix layer; and
irradiating the extra cellular matrix layer and Riboflavin or Riboflavin-5-phosphate with light energy to crosslink the extra cellular matrix layer. - View Dependent Claims (23, 24, 25, 26, 27)
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28. A method for crosslinking an extra cellular matrix layer in the vascular system of the body comprising:
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delivering a photoxidizer to the extra cellular matrix layer; and
irradiating the extra cellular matrix layer and photooxidizer with light energy to crosslink the extra cellular matrix layer.
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29. A vascular catheter for delivering light energy to a blood vessel wall comprising:
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a light-emitting diode (LED) on the distal end of the catheter, a transparent balloon mounted over the LED; and
a lumen opening distal and proximal to the balloon. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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Specification