Drug delivery through encapsulation

• US 20040230182A1
• Filed: 12/23/2003
• Published: 11/18/2004
• Est. Priority Date: 12/27/2002
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Heruth, Kenneth T., Lent, Mark S.
• Application Number:
  US10/745,720
• Publication Number:
  US 20040230182A1
• Time in Patent Office: Days
• US Class Current: 604/891.1
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

An implantable drug delivery device having a drug releaser that releases a drug from a capsule in the catheter. The drug delivery device includes a reservoir configured to store a drug capsule, a catheter, a pump configured to move the drug capsules into the catheter, and a drug releaser. The drug releaser is connected to the catheter for freeing at least a portion of the drug from one or more of the drug capsules while in the catheter.

Claims

1. An implantable drug delivery device comprising:

a reservoir configured to store a drug capsule;

a catheter having a proximal end and a distal end, wherein the catheter has a first lumen and wherein the proximal end is connected to the reservoir for receiving the drug capsule from the reservoir into the first lumen;

a pump configured to convey the drug capsules to the catheter; and

a drug releaser connected to the catheter for freeing at least a portion of a drug from one or more of the drug capsules.

2. The implantable drug delivery device of claim 1 further comprising a drug capsule in the reservoir.

3. The implantable drug delivery device of claim 2 further comprising a carrier fluid in the reservoir, wherein the carrier fluid will dissolve the drug when the drug is released from the drug capsule, and wherein the pump is configured to convey the carrier fluid and drug capsule to the catheter.

4. The device of claim 1, wherein the drug releaser comprises an ultrasonic sound emitter that emits sufficient sound waves to release the drug from the drug capsule.

5. The device of claim 1, wherein the drug releaser from the capsule comprises a mechanical crushing or grinding device that exerts sufficient force to break the capsule open.

6. The device of claim 1, wherein the drug releaser comprises a chemical dissolving or chemical splitting apparatus to release the drug from the capsule.

7. The device of claim 6, wherein the chemical dissolving or chemical splitting apparatus is citric acid.

8. The device of claim 6, wherein the catheter further comprises a second lumen for delivering the chemical dissolving or chemical splitting apparatus to the first lumen.

9. The device of claim 8, wherein the catheter includes a port connecting the first lumen to the second lumen.

10. The device of claim 9, wherein the catheter includes a valve located at the port for controlling the movement of fluid through the port.

11. The device of claim 1, wherein the drug releaser comprises an electrical current emitter to potentiate a chemical reaction in the capsule sufficient to release the drug from the capsule.

12. The device of claim 1, wherein the drug releaser comprises a heater that conveys sufficient heat to the capsule to release the drug from the capsule.

13. The device of claim 1, wherein the drug releaser comprises a pressure device that exerts sufficient pressure on the capsule to break the capsule open to enable release of the drug from the capsule.

14. The device of claim 1, wherein the device further has a sensor that senses the physiological conditions at a target site.

15. The device of claim 1, wherein the device is programmed for drug delivery to a target site.

16. The device of claim 1, wherein the device is programmed for drug delivery to a target site via telemetry.

17. The device of claim 14, wherein the device has an electrical control circuit that receives sensed signals from the sensor and controls the drug releaser based on the sensed signals.

18. The device of claim 14, wherein the device has an electrical control circuit that receives sensed signals from the sensor and controls the amount of the drug delivered based on the sensed signals.

19. The device of claim 14, wherein the device has a drug releaser responsive to the sensed signal for regulating a therapeutic dosage of the drug to the target site.

20. The device of claim 1, wherein the device further has a premixing vessel that contains the drug capsules and that delivers the drug capsules to the reservoir for mixing with the carrier fluid.

21. The device of claim 1, further comprising a filter in the catheter, the filter located between the drug releaser and the distal end of the catheter.

22. A method for drug delivery by an implantable pump and a catheter having a discharge portion and having a proximal end coupled to said pump, said method comprising:

implanting the pump in a patient;

implanting said catheter so that said discharge portion lies adjacent a predetermined infusion site in the patient;

supplying to a reservoir at least one capsule containing a drug;

supplying to the reservoir a carrier fluid capable of dissolving the drug;

releasing the drug from the capsule in the catheter;

dissolving the drug in the carrier fluid to form a mixture; and

pumping the mixture to and through the discharge portion of the catheter and to the infusion site.

23. The method of claim 22, wherein releasing the drug from the capsule comprises subjecting the capsule to sound waves sufficient to break open the capsule.

24. The method of claim 22, wherein releasing the drug from the capsule comprises subjecting the capsule to a mechanical force sufficient to break open the capsule.

25. The method of claim 22, wherein releasing the drug from the capsule comprises subjecting the capsule to a chemical sufficient to dissolve or split the capsule.

26. The method of claim 22, wherein releasing the drug from the capsule comprises subjecting the capsule to an electrical current to potentiate a chemical reaction in the capsule sufficient to release the drug from the capsule.

27. The method of claim 22, wherein releasing the drug from the capsule comprises subjecting the capsule to heat sufficient to release the drug from the capsule.

28. The method of claim 22, wherein releasing the drug from the capsule comprises subjecting the capsule to pressure sufficient to release the drug from the capsule.

29. The method of claim 22, wherein the method further comprises sensing a physiological condition at the infusion site.

30. The method of claim 22, wherein the method further comprises sensing an amount of a substance related to a physiological condition at the infusion site.

31. The method of claim 29, wherein the method further comprises controlling the amount of drug delivery to the infusion site based on the physiological condition sensed at the infusion site.

32. The method of claim 30, wherein the method further comprises controlling the amount of drug delivery to the infusion site based on the amount of the substance sensed at the infusion site.

33. The method of claim 22, wherein the method further comprises programming an electrical circuit to control the amount of drug delivery to the infusion site.

34. The method of claim 22, wherein the method further comprises programming an electrical circuit via telemetry to control the amount of drug delivery to the infusion site.

35. The method of claim 22, wherein the method further comprises removing capsules after the drug is released from the capsule.

36. The method of claim 35, wherein the method further comprises replenishing the reservoir with at least one new capsule containing a drug through a port in the reservoir.

37. The method of claim 22, wherein the method further comprises controlling the delivery of the drug to the infusion site based on a measurement of the concentration of the drug within the carrier fluid.

38. The method of claim 22, wherein the method further comprises implanting in the patient a premixing vessel containing the capsulated drug, and supplying the capsulated drug to the reservoir from the premixing vessel.

39. The method of claim 22, further comprising filtering the carrier fluid and drug after the drug has been released from the capsule.

40. The method of claim 22, further comprising removing capsules through a catheter access port.

41. A catheter comprising:

a first lumen;

a second lumen; and

a port connecting the first lumen to the second lumen allowing mixing of two fluids within the catheter.