Membrane for use in guided tissue regeneration
First Claim
1. A membrane comprising a resorbable multi-layer membrane for use in vivo in the reconstruction of bone or cartilage tissue, said resorbable multi-layer membrane comprising a matrix layer having a matrix consisting essentially of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture, the at least one barrier layer consisting essentially of a barrier layer material selected from the group consisting of collagen I, collagen III and a mixture thereof, wherein said multi-layer membrane is formed by adhering of said matrix layer to said at least one barrier layer by non-sutured adhesive, so that said matrix layer is adhered firmly to and in direct contact with said at least one barrier layer.
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Abstract
The invention provides a multi-layer membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture. Such a membrane is particularly suitable for use in guided tissue regeneration, in particular for use in vivo in the reconstruction of bone or cartilage tissue.
12 Citations
20 Claims
- 1. A membrane comprising a resorbable multi-layer membrane for use in vivo in the reconstruction of bone or cartilage tissue, said resorbable multi-layer membrane comprising a matrix layer having a matrix consisting essentially of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture, the at least one barrier layer consisting essentially of a barrier layer material selected from the group consisting of collagen I, collagen III and a mixture thereof, wherein said multi-layer membrane is formed by adhering of said matrix layer to said at least one barrier layer by non-sutured adhesive, so that said matrix layer is adhered firmly to and in direct contact with said at least one barrier layer.
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19. A membrane comprising a resorbable multi-layer membrane for use in vivo in the reconstruction of bone or cartilage tissue at a site of a defect in said tissue, said resorbable multi-layer membrane comprising a matrix layer having a matrix comprising collagen I, collagen III or a mixture thereof, and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture, the at least one barrier layer comprising a barrier layer comprising collagen I, collagen III or a mixture thereof, wherein said multi-layer membrane is formed by application of said matrix layer to said at least one barrier layer as a slurry, so that said matrix layer is adhered firmly to and in direct contact with said at least one barrier layer, wherein firm adherence of the matrix layer to said at least one barrier layer results essentially solely from application of said slurry to said at least one barrier layer.
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20. A membrane comprising a resorbable multi-layer membrane for use in vivo in the reconstruction of bone or cartilage tissue at a site of a defect in said tissue, said resorbable multi-layer membrane comprising a matrix layer having a matrix comprising collagen I, collagen II or a mixture thereof, and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture, the at least one barrier layer comprising collagen I, collagen III or a mixture thereof, wherein said multi-layer membrane is formed by application of said matrix layer to said at least one barrier layer by non-sutured adhesive, so that said matrix layer is adhered firmly to and in direct contact with said at least one barrier layer.
Specification