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Diagnostics and therapeutics for the gene expression signature of PPAR-gamma receptor ligand

  • US 20040235019A1
  • Filed: 03/03/2004
  • Published: 11/25/2004
  • Est. Priority Date: 03/06/2003
  • Status: Abandoned Application
First Claim
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1. A method for identifying a therapeutic having analogous activity to a thiazolidinedione comprising contacting a cell containing a PPARγ

  • receptor with a candidate therapeutic; and

    determining the level of expression of at least one gene selected from the panel of genes in Table I and/or Table II, wherein an increase in the level of expression of at least one gene of Tables I or III and/or a decrease in the level of expression of at least one gene of Tables II or IV in the cell treated with the candidate therapeutic relative to a cell that was not treated with the candidate therapeutic indicates that the candidate therapeutic is a therapeutic for treating a disease associated with a PPARγ

    receptor.

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