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PUFA polyketide synthase systems and uses thereof

  • US 20040235127A1
  • Filed: 03/26/2004
  • Published: 11/25/2004
  • Est. Priority Date: 01/14/1999
  • Status: Active Grant
First Claim
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1. An isolated nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of:

  • a) a nucleic acid sequence encoding an amino acid sequence selected from the group consisting of;

    SEQ ID NO;

    39, SEQ ID NO;

    41, SEQ ID NO;

    43, SEQ ID NO;

    45, SEQ ID NO;

    48, SEQ ID NO;

    50, SEQ ID NO;

    52, SEQ BD NO;

    54, SEQ ID NO;

    56, SEQ ID NO;

    58, SEQ ID NO;

    60, SEQ ID NO;

    62, SEQ ID NO;

    64, SEQ ID NO;

    66, SEQ ID NO;

    68 and biologically active fragments thereof;

    b) a nucleic acid sequence encoding an amino acid sequence that is at least about 60% identical to an amino acid sequence selected from the group consisting of;

    SEQ ID NO;

    39, SEQ ID NO;

    43, SEQ ID NO;

    50, SEQ ID NO;

    52, SEQ ID NO;

    56 and SEQ ID NO;

    58, wherein the amino acid sequence has a biological activity of at least one domain of a polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) system;

    c) a nucleic acid sequence encoding an amino acid sequence that is at least about 65% identical to SEQ ID NO;

    54, wherein the amino acid sequence has a biological activity of at least one domain of a polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) system;

    d) a nucleic acid sequence encoding an amino acid sequence that is at least about 70% identical to an amino acid sequence selected from the group consisting of;

    SEQ ID NO;

    45, SEQ ID NO;

    48, SEQ ID NO;

    60, SEQ ID NO;

    62 and SEQ ID NO;

    64, wherein the amino acid sequence has a biological activity of at least one domain of a polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) system;

    e) a nucleic acid sequence encoding an amino acid sequence that is at least about 80% identical to an amino acid sequence selected from the group consisting of;

    SEQ ID NO;

    41, SEQ ID NO;

    66, SEQ ID NO;

    68, wherein the amino acid sequence has a biological activity of at least one domain of a polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) system; and

    f) a nucleic acid sequence that is fully complementary to the nucleic acid sequence of (a), (b), (c), (d), or (e).

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