Method for preventing the formation of adhesions following surgery or injury
First Claim
1. A method for augmenting soft or hard tissue within a mammalian body, comprising:
- (a) providing a first crosslinkable component having m nucleophilic groups, wherein m≧
2;
(b) providing a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧
2 and m+n≧
5;
(c) applying the first and second crosslinkable components to the tissue; and
(d) allowing the first and second crosslinkable components to crosslink in situ, wherein the first and second crosslinkable components are biocompatible, synthetic, and nonimmunogenic.
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Accused Products
Abstract
Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.
141 Citations
68 Claims
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1. A method for augmenting soft or hard tissue within a mammalian body, comprising:
-
(a) providing a first crosslinkable component having m nucleophilic groups, wherein m≧
2;
(b) providing a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧
2 and m+n≧
5;
(c) applying the first and second crosslinkable components to the tissue; and
(d) allowing the first and second crosslinkable components to crosslink in situ, wherein the first and second crosslinkable components are biocompatible, synthetic, and nonimmunogenic. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A method for preventing the formation of adhesions following surgery or injury, comprising:
-
(a) providing a first crosslinkable component having m nucleophilic groups, wherein m≧
2;
(b) providing a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧
2 and m+n≧
5;
(c) applying the first and second crosslinkable components to the tissues comprising, surrounding, and/or adjacent to a wound resulting from surgery or injury; and
(d) allowing the first and second crosslinkable components to crosslink in situ, wherein the first and second crosslinkable components are biocompatible, synthetic, and nonimmunogenic. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68)
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Specification