Unit dosage powder container

• US 20040236282A1
• Filed: 06/28/2004
• Published: 11/25/2004
• Est. Priority Date: 06/07/2001
• Status: Abandoned Application

• Current Assignee: Innovata Biomed Limited (Vectura Group Ltd.)
• Original Assignee: Innovata Biomed Limited (Vectura Group Ltd.)
• Inventors: Braithwaite, Philip
• Application Number:
  US10/479,940
• Publication Number:
  US 20040236282A1
• Time in Patent Office: Days
• US Class Current: 604/158
• CPC Class Codes: A61M 15/0036 hollow piercing means
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0048 the dosages being arranged in a plane, e.g. on diskettes
• CPC Class Codes: A61M 15/0051 the dosages being arranged on a tape, e.g. strips
• CPC Class Codes: A61M 15/0061 using pre-packed dosages having an insert inside
• CPC Class Codes: A61M 2202/064 Powder

Abstract

There is described a unit dosage powder receptacle which receptacle is provided with a frangible sealing member characterised in that the receptacle is provided with means to enable the frangible sealing member to be ruptured by inserting a powder flow channel through the sealing member such that the sealing member ruptures in a direction away from the powder. There is also described a rupturing member adapted for rupturing such a unit dosage powder receptacle and also a powder delivery device comparing a unit dosage powder receptacle and a method of treatment related thereto.

Claims

1. A unit dosage powder receptacle (31) with receptacle is provided with a frangible sealing member (312) receptacle is provided with means to enable the frangible sealing member (312) to be ruptured by inserting a powder flow channel (729) through the sealing member (312) characterised in that the sealing member ruptures in a direction away from the powder.

2. A unit dosage powder receptacle (31) according to claim 1 characterised in that the powder is held in a powder reservoir (34) in a plane which is substanially perpendicular to the plane of the frangible sealing member (312).

3. A unit dosage powder receptacle (31) according to claim 1 characterised in that the powder is held in a powder reservoir (34) provided with a powder protector (33).

4. A unit dosage powder receptacle (31) according to claim 3 characterised in that the powder reservoir (34) and powder protector (33) comprises a spool/spool sleeve assembly (34 and 33).

5. A unit dosage powder receptacle (31) according to claim 4 characterised in that the spool/spool sleeve assembly (34 and 33) comprises an assembly as described in European Patent No. 0 626 869.

6. A unit dosage powder receptacle (31) according to claim 4 characterised in that the spool/spool sleeve assembly (33 and 34) is housed in a spool receptacle.

7. A unit dosage powder receptacle according to claim 5 characterised in that the receptacle is substantially frusto conical in shape.

8. A unit dosage powder receptacle according to claim 4 characterised in that the spool/spool sleeve is positioned such that a fit end is positioned adjacent the frangible sealing member and a second end is positioned adjacent the base of the recycle.

9. A unit dosage powder receptacle according to claim 8 charaterised in that the frusto conical nature of the rectangle is such that the second end of the spool forms a snug fit with the receptacle while the conical sides of the receptacle slope away from the first end of the spool.

10. A unit dosage powder receptacle according to claim 9 characterised in that the second end of the spool is located against a spigot.

11. A unit dosage powder receptacle according to claim 10 characterised in that the spigot is integral to the spool.

12. A unit dosage powder receptacle according to claim 10 charaterised in that the spigot is integral to the receptacle.

13. A unit dosage powder receptacle according to claim 10 charaterised in that the receptacle is provided with a recessed portion in which the spigot sits.

16. A unit dosage powder receptacle according to claim 1 characterised in that the dimensions are such that the powder reservoir is filled to provide a single desired dose.

17. A unit dosage powder receptacle according to claim 4 characterised in that the spool and/or the spool sleeve substantially abuts the frangible sealing member.

18. A unit dosage powder receptacle according to claim 17 characterised in that the frangible sealing member is fixed to the chamber.

19. A unit dosage powder receptacle according to claim 1 characterised in that the frangible sealing member comprises a material which is substantially impermeable to moisture and/or is moisture resistant.

20. A unit dosage powder receptacle according to claim 19 characterised in that the frangible sealing member comprises a plastics film or foil.

21. A unit dosage powder receptacle according to claim 20 characterised in that the frangible sealing member comprises an aluminium foil material.

22. A unit dosage powder receptacle according to claim 20 characterised in that the frangible sealing member comprises a plastics material that is heat bonded to the receptacle.

23. A unit dosage powder receptacle according to claim 21 characterised in that the frangible seating member comprises a foil material that is bonded to the receptacle with an adhesive.

24. A rupturing member adapted for rupturing the frangible sealing member of a unit dosage powder receptacle according to claim 1 characterised in that the rupturing member is adapted to act as a rupturing member, a spool/spool holder separator and a powder channel.

25. A rupturing member according to claim 24 characterised in that the rupturing member is adapted to rupture the frangible sealing member in a direction away from the powder.

26. A rupturing member according to claim 24 characterised in that the rupturing member is provided with one or more surfaces which are adapted to be coincident with the walls of the receptacle.

27. A rupturing member according to claim 26 characterised in that the rupturing member comprises a pair of inclined walls adapted to be coincident with the walls of the inclined region of the receptacle.

28. A rupturing member according to claim 27 characterised in that the end of the inclined walls of the rupturing member may form a cutting point.

29. A rupturing member according to claim 24 characterised in that the rupturing member is provided with one or more conduits which act as a powder conduit.

30. A rupturing member according to claim 29 characterised in that the rupturing member is provided with a pair of powder conduits.

31. A rupturing member according to claim 29 characterised in that the rupturing member is adapted for the introduction of flushing air into the powder receptacle.

32. A powder delivery device which comprises a unit dosage powder receptacle according to claim 1.

33. A powder delivery device according to claim 32 characterised in that the delivery device includes means for rupturing the frangible sealing member.

34. A powder delivery device according to claim 33 characterised in that the rupturing means is also adapted to urge the separation of the spool and the spool sleeve.

35. A powder delivery device according to claim 34 characterised in that the rupturing means is adapted to act on the spool to slidably urge the separation of the spool sleeve away from the spool.

36. A powder delivery device according to claim 33 characterised in that the rupturing means is also adapted to act as a powder channel.

37. A powder delivery device according to claim 36 characterised in that at the point when the powder and/or spool are exposed the powder channel is placed adjacent to or in intimate contact with the powder and/or spool.

38. A powder delivery device according to claim 36 characterised in that the powder conduit of the rupturing member is adapted to overlie all or part of the powder when the rupturing member is fully inserted.

39. A unit dosage powder receptacle according to claim 1 characterised in that a plurality of dosage units are arranged in series.

40. A cartridge comprising a series of unit dosage powder receptacles according to claim 39.

41. A powder delivery device according to claim 29 characterised in that the powder is a medicament.

42. A powder delivery device according to claim 41 characterised in that the delivery device is an inhaler.

43. A powder delivery device according to claim 42 characterised in that the delivery device is a dry powder inhaler.

44. A powder delivery device according to claim 1 characterised in that the as device comprises a plurality of unit dosage powder receptacles.

45. A powder delivery device according to claim 43 characterised in that the powder channel is air channel.

46. A powder delivery device according to claim 41 characterised in that the device is provided with suitable indexing means.

47. A powder delivery device according to claim 41 characterised in that the powder is selected from the group of drugs for the treatment of asthma, COPD or, respiratory infections such as β

₂-agonists, e.g. fenoterol, formoterol, pirbuterol, reproterol, rimiterol, salbutamol, salmeterol and terbutaline;

non-selective beta-stimulants such as isoprenaline;

xanthine bronchodilators, e.g. theophylline, aminophylline and choline theophullinate;

anticholinergics, e.g. ipratropium bromide;

mast cell stabilisers, e.g. sodium cromoglycate and ketoifen;

bronchial anti-inflammatory agents, e.g. nedocromil sodium; and

steriods, e.g. beclomethasone dipropionate, fluticasone, budesonide, fluisolide and ciclesonide, and isomers and/or salts or derivatives thereof.

48. A powder delivery device according to claim 47 characterised in that device comprises a combination of medicaments, selected from steroids, such as beclomethasone dipropionate and formoterol;

beclomethasone dipropionate and salmeterol;

fluticasone and formoterol;

fluticasone and salmeterol;

budesonide and formoterol;

budesonide and salmeterol;

flunisolide and formoterol; and

flunisolide and salmeterol.

49. A powder delivery device according to claim 41 characterised in that device comprises a systemically active materials, such as, proteinaceous compounds and/or macromolecules, for example, hormones and mediators, such as insulin, human growth hormone, leuprolide and alpha interferon;

growth factors, anticoagulants, immumonomodulators, cytokines and nucleic acids.

50. A method of delivering a powder which comprises the use of a powder delivery device according to claim 41.

51. A method of treatment of a patient with a respiratory disorder which comprises the administration of a medicament using a powder delivery device according to claim 42.

52. A method of treatment of a patient with a systemic disorder which comprises the administration of a medicament using a powder delivery device according to claim 41.

14. A unit dosage powder receptacle according to claim 14 charaterised in that the recessed portion also forms a snug fit with the spool sleeve.

15. A unit dosage powder receptacle according to claim 14 charaterised in that the depth of the recess is substantially similar to the length of the spool sleeve.

53. A unit dosage powder receptacle, rupturing member or powder delivery device substantially as described with reference to the accompanying drawings.