Transdermal therapeutic system based on polyacrylate-contact-bonding adhesives without functional groups
First Claim
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1. A transdermal therapeutic system comprising back layer, protective layer and at least one active-compound-containing polymer matrix comprising a polyacrylate, the polyacrylate being a homopolymer, copolymer or block copolymer which can be prepared by polymerization of a monomer mixture consisting of:
- a) a monomer or a mixture of monomers from the group consisting of the esters of acrylic or methacrylic acid, which carry linear, branched and/or cyclic aliphatic C1-C12 substituents without another functional group, b) acrylic acid, methacrylic acid, 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, 3-hydroxypropyl acrylate and/or 3-hydroxypropyl methacrylate, the content of these monomers in the total being below 2% by weight, c) vinyl acetate in a content of below 20% by weight, d) crosslinkers in a content of below 0.5% by weight e) auxiliaries from the group consisting of the antioxidants, stabilizers and/or alkylmercaptans in a content of below 0.1% by weight.
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Abstract
The invention relates to a transdermal therapeutic system (TTS) consisting of a rear layer, a protective layer and an active-substance-containing polymer layer. The polymer matrix comprises a polyacrylate which contains an extremely reduced number of functional groups. In one particular embodiment, the polyacrylate is free from hydroxyl groups and/or carboxyl groups.
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10 Claims
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1. A transdermal therapeutic system comprising back layer, protective layer and at least one active-compound-containing polymer matrix comprising a polyacrylate, the polyacrylate being a homopolymer, copolymer or block copolymer which can be prepared by polymerization of a monomer mixture consisting of:
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a) a monomer or a mixture of monomers from the group consisting of the esters of acrylic or methacrylic acid, which carry linear, branched and/or cyclic aliphatic C1-C12 substituents without another functional group, b) acrylic acid, methacrylic acid, 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, 3-hydroxypropyl acrylate and/or 3-hydroxypropyl methacrylate, the content of these monomers in the total being below 2% by weight, c) vinyl acetate in a content of below 20% by weight, d) crosslinkers in a content of below 0.5% by weight e) auxiliaries from the group consisting of the antioxidants, stabilizers and/or alkylmercaptans in a content of below 0.1% by weight. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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