Angiogenesis promotion by prostaglandin compositions and methods
First Claim
1. A composition comprising between 0.001 weight percent and 1 weight percent of a vasoactive prostaglandin selected from the group consisting of prostaglandin E1, prostaglandin E2, a pharmaceutically acceptable salt thereof, a lower alkyl ester thereof and mixtures thereof, based on the total weight of the composition;
- a biocompatible polymer;
a lipophilic component selected from the group consisting of a C1 to C8 aliphatic alcohol, a C8 to C30 aliphatic ester, a liquid polyol and a mixture thereof;
water; and
a buffer that provides a buffered pH value for the composition in the range of about 3 to about 7.4.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides compositions and methods for promoting the recovery of vascular function in erectile dysfunction associated with vasculopathy by administering a composition comprising a vasoactive prostaglandin and a biocompatible polymer. In preferred embodiments, the prostaglandin composition is a topical composition comprising prostaglandin E1, a biocompatible polymer and a penetration enhancer and the topical composition is applied to the meatus at the tip of the penis. In another embodiment, the invention provides a method for increasing microvascular outgrowth at a targeted arterial segment comprising administering a prostaglandin E1 composition to produce an extracellular prostaglandin E1 concentration of about 1 micromolar to about 10 micromolar adjacent to the targeted arterial segment for about four days.
-
Citations
26 Claims
-
1. A composition comprising
between 0.001 weight percent and 1 weight percent of a vasoactive prostaglandin selected from the group consisting of prostaglandin E1, prostaglandin E2, a pharmaceutically acceptable salt thereof, a lower alkyl ester thereof and mixtures thereof, based on the total weight of the composition; -
a biocompatible polymer;
a lipophilic component selected from the group consisting of a C1 to C8 aliphatic alcohol, a C8 to C30 aliphatic ester, a liquid polyol and a mixture thereof;
water; and
a buffer that provides a buffered pH value for the composition in the range of about 3 to about 7.4. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
- 12. A method of promoting the recovery of vascular function in a subject having erectile dysfunction comprising the step of administering a composition comprising a vasoactive prostaglandin selected from the group consisting of prostaglandin E1, prostaglandin E2, pharmaceutically acceptable salts thereof, lower alkyl esters thereof, mixtures thereof, a biocompatible polymer and a buffer that provides a buffered pH value for the composition of about 3 to about 7.4, wherein vascular recovery is demonstrable by objective measures or by clinical findings.
- 19. A method of causing microvascular sprouting in a targeted arterial segment comprising contacting the targeted segment with a solution comprising about 1 micromolar to about 100 micromolar of a vasoactive prostaglandin selected from the group consisting of prostaglandin E1 and prostaglandin E2.
Specification