Microfluidic structures with circumferential grooves for bonding adhesives and related optical analysis discs

• US 20040241381A1
• Filed: 01/21/2003
• Published: 12/02/2004
• Est. Priority Date: 01/31/2002
• Status: Abandoned Application

• Current Assignee: Nagaoka & Co., Ltd.
• Original Assignee: Nagaoka & Co., Ltd.
• Inventors: Chen, YihFar
• Application Number:
  US10/348,196
• Publication Number:
  US 20040241381A1
• Time in Patent Office: Days
• US Class Current: 428/66.6
• CPC Class Codes: B01L 2200/0689 Sealing
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/0806 Standardised forms, e.g. compact disc [CD] format
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B29C 65/00 Joining or sealing of preformed parts , e.g. welding of plastics materials; Apparatus therefor general aspects of processes or apparatus for joining preformed parts B29C66/00; using porous material formed by internal pressure generated therein for joining preformed parts B29C44/1228, B29C44/326
• CPC Class Codes: B29C 65/1406 Ultraviolet [UV] radiation
• CPC Class Codes: B29C 65/48 using adhesives , i.e. using supplementary joining material; solvent bonding
• CPC Class Codes: B29C 65/4845 Radiation curing adhesives, e.g. UV light curing adhesives
• CPC Class Codes: B29C 65/52 characterised by the way of applying the adhesive B29C65/50 takes precedence; apparatus for applying liquids in general B05C; processes for applying liquids in general B05D
• CPC Class Codes: B29C 66/1122 Single lap to lap joints, i.e. overlap joints B29C66/45, B29C66/472, B29C66/52272 take precedence
• CPC Class Codes: B29C 66/452 the article having a disc form, e.g. making CDs or DVDs
• CPC Class Codes: B29C 66/543 joining more than two hollow-preforms to form said hollow articles
• CPC Class Codes: B29C 66/71 characterised by the composition of the plastics material of the parts to be joined welding bar compositions B29C65/125
• CPC Class Codes: B29C 66/73341 at least one of the parts to be joined being glossy or reflective
• CPC Class Codes: B29C 66/863 Robotised, e.g. mounted on a robot arm
• CPC Class Codes: B29D 17/005 Producing optically read record carriers, e.g. optical discs
• CPC Class Codes: B29K 2069/00 Use of PC, i.e. polycarbonates or derivatives thereof, as moulding material
• CPC Class Codes: B29L 2031/756 Microarticles, nanoarticles
• CPC Class Codes: G01N 35/00069 whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
• CPC Class Codes: Y10T 428/218 : Aperture containing

Abstract

A process for manufacturing optical analysis discs with micro-fluidic structures and discs made according thereto. The process includes the steps of providing a lens disc, providing a cover disc having micro-fluidic structures having bonding grooves, dispensing adhesive material inside the bonding grooves, and applying the cover disc onto the lens disc to bond them together.

Claims

1. A process for manufacturing optical analysis discs with microfluidic structures including the steps of:

providing a lens disc;

providing a cover disc having molded microfluidic structures including bonding grooves; and

dispensing adhesive material inside said bonding grooves and applying said cover disc onto the lens disc to bond them together.

2. The process for manufacturing optical analysis discs according to claim 1 wherein a chemistry deposition is integrated into the lens disc.

3. The process for manufacturing optical analysis discs according to claim 1 wherein said adhesive material is UV curable epoxy adhesive.

4. The process for manufacturing optical analysis discs according to claim 1 wherein the step of providing a cover disc having molded microfluidic structures inside includes the steps of:

providing a mastering support;

coating the mastering support with a photoresist composition;

transferring onto said mastering support a pattern design of microfluidic structures;

developing said photoresist composition according to said pattern design;

depositing a metal layer onto the mastering support until a plated stamper is obtained;

peeling of said plated stamper; and

molding said microfluidic structures in a cover disc according said plated stamper.

5. The process for manufacturing optical analysis discs according to claim 4 wherein said mastering support is a mastering glass.

6. The process for manufacturing optical analysis discs according to claim 4 wherein said mastering support is prepared by a process of cleaning.

7. The process for manufacturing optical analysis discs according to claim 4 wherein said photoresist composition is selected in a group consisting of AZ54I2, AZ4620, SU8-5, SU8-25, SU8-50, and SU8-100.

8. The process for manufacturing optical analysis discs according to claim 4 wherein said coating of a photoresist composition is carried out by dipping, spray coating, or spin coating.

9. The process for manufacturing optical analysis discs according to claim 4 wherein the steps of coating the mastering support with a photoresist composition;

transferring onto said mastering support a pattern design of microfluidic structures; and

developing said photoresist composition according to said pattern design are repeated to obtain multi-layer microfluidic structures.

10. The process for manufacturing optical analysis discs according to claim 4 wherein the depositing of a metal layer is carried out by vacuum deposition.

11. Optical analysis disc, comprising:

a lens disc element; and

a cover disc element having micro-fluidic structures formed therein, said micro-fluidic structures including bonding grooves having adhesive material to bond said cover disc element and to said lens disc element.

12. The optical analysis disc according to claim 11 wherein a chemistry deposition is integrated into said lens disc element.

13. The optical analysis disc according to claim 11 wherein said adhesive material is UV curable epoxy adhesive.

14. A microfluidic structure molded in a substrate layer comprising at least one chamber surrounded by a circumferential bonding groove having a predetermined cross section, said microfluidic structure adapted to be filled with an adhesive material.

15. The microfluidic structure according to claim 14 comprising a chamber like leg and a channel like leg, said legs being separated by an intermediate portion, peripheral grooves being formed around both the legs, at the intermediate portion the grooves being merged in a single groove.

16. An optical analysis disc, comprising:

a cap element;

a channel layer; and

a substrate, said cap element, said channel layer, and said substrate assembled to form micro-fluidic circuits having bonding grooves.

17. The optical analysis disc according to claim 16 further including micro-fluidic elements formed only in said cap element, said micro-fluidic elements associated with said channel layer to form said micro-fluidic circuits.

18. The optical analysis disc according to claim 16 further including micro-fluidic elements formed only in said substrate, said micro-fluidic elements associated with said channel layer to form said micro-fluidic circuits.

19. The optical analysis disc according to claim 16 further including micro-fluidic elements formed only in said channel layer, said micro-fluidic elements associated with said cap element and said substrate to form said micro-fluidic circuits.

20. The optical analysis disc according to claim 16 further including micro-fluidic elements formed in said cap element and said channel layer, said micro-fluidic elements associated with said substrate layer to form said micro-fluidic circuits.

21. The optical analysis disc according to claim 16 further including micro-fluidic elements formed in said channel layer and said substrate, said micro-fluidic elements associated with said cap element to form said micro-fluidic circuits.

22. The optical analysis disc according to claim 16 further including micro-fluidic elements formed in said cap element, said channel layer, and said substrate, said cap element, channel layer, said substrate assembled to thereby form said micro-fluidic circuits by aligning said micro-fluidic elements.

23. An optical analysis disc, comprising:

a cap element; and

a substrate, said cap element and said substrate assembled to form micro-fluidic circuits having bonding grooves.

24. The optical analysis disc according to claim 23 further including micro-fluidic elements formed only in said cap element, said micro-fluidic elements associated with said substrate to form said micro-fluidic circuits.

25. The optical analysis disc according to claim 23 further including micro-fluidic elements formed only in said substrate, said micro-fluidic elements associated with said cap element to form said micro-fluidic circuits.

26. The optical analysis disc according to claim 23 further including micro-fluidic elements formed in said cap element and said substrate, said cap element and said substrate assembled to thereby form said micro-fluidic circuits by aligning said micro-fluidic elements.