Open channel solid phase extraction systems and methods
First Claim
1. A method of extracting an analyte from a solution comprising the steps of:
- a. passing a solution containing an analyte through an extraction channel having a solid phase extraction surface, whereby analyte adsorbs to the extraction surface of said extraction channel; and
b. eluting the analyte by passing a desorption solvent through the channel, wherein the volume of desorption solvent is in the range of 10 μ
L to 500 μ
L.
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Abstract
The invention provides, inter alia, methods of extracting an analyte from a solution comprising the steps of: passing a solution containing an analyte through an extraction channel having a solid phase extraction surface, whereby analyte adsorbs to the extraction surface of said extraction channel; and eluting the analyte by passing a small volume of desorption solvent through the channel. The invention also provides, inter alia, methods of extracting an analyte from a solution comprising the steps of: passing a solution containing an analyte through an extraction channel having a solid phase extraction surface, whereby analyte adsorbs to the extraction surface of said extraction channel; eluting the analyte by passing a desorption solvent through the channel; and collecting the eluted analyte, wherein a small volume of eluant is collected.
50 Citations
40 Claims
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1. A method of extracting an analyte from a solution comprising the steps of:
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a. passing a solution containing an analyte through an extraction channel having a solid phase extraction surface, whereby analyte adsorbs to the extraction surface of said extraction channel; and
b. eluting the analyte by passing a desorption solvent through the channel, wherein the volume of desorption solvent is in the range of 10 μ
L to 500 μ
L. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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9. The method of claim 86, wherein said extraction surface remains substantially solvated during said purge step.
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26. A method of extracting an analyte from a solution comprising the steps of:
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a. passing a solution containing an analyte through an extraction channel having a solid phase extraction surface, whereby analyte adsorbs to the extraction surface of said extraction channel;
b. eluting the analyte by passing a desorption solvent through the channel; and
c. collecting the eluted analyte, wherein the volume of collected eluant is in the range of 10 pL to 500 μ
L. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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Specification