High throughput screening assay systems in microscale fluidic devices
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Abstract
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
5 Citations
26 Claims
- 1. Cancelled.
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2. A method of screening one or more test compounds for an effect on at least one cell using an analytical device comprising:
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flowing one or more test compounds from one or more test compound sources through one or more microfluidic channels of the device, wherein the one more microfluidic channels have at least one cross-sectional dimension in a range from about 0.1 to 500 μ
m;
contacting the one or more test compounds with at least a first cell; and
detecting a cellular response of the at least first cell to the one or more test compounds in a detection zone of the device. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification