Analyte determinations
First Claim
Patent Images
1. A method of determining an attribute of a sample, comprising:
- a. Determining a spectrum of the sample using a controlled pathlength; and
b. Determining the attribute from the spectrum.
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Abstract
A method and apparatus for determining an attribute of a sample from a spectrum of the sample. The invention comprises samplers and methods of sampling that provide controlled optical pathlengths through the sample, increasing the accuracy of the attribute determinations. The invention is applicable, for example, in determining analyte concentrations in biological samples, such as concentrations of analytes such as glucose in human blood.
102 Citations
26 Claims
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1. A method of determining an attribute of a sample, comprising:
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a. Determining a spectrum of the sample using a controlled pathlength; and
b. Determining the attribute from the spectrum. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An apparatus for determining an attribute of a sample, comprising:
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a. A sample holder;
b. A sampling apparatus providing an optical path traversing the sample having a controlled optical pathlength;
c. An optical system that determines a spectrum of the sample from interaction of light with the sample along the optical path;
d. A processing system that determines the attribute from the spectrum. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. An apparatus for determining an attribute of a patient'"'"'s blood, comprising:
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a. A recirculating blood loop, in fluid communication with the patient'"'"'s blood;
b. An optical sampling system, in optical communication with the recirculating blood loop and adapted to determine a spectrum of blood in the recirculating blood loop;
c. A processing system that determines the attribute from the spectrum
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Specification