Non-invasive methods of detecting analyte concentrations using hyperosmotic fluids
First Claim
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1. A non-invasive method of determining the concentration of an analyte comprising:
- topographically applying a hyperosmotic solution to an area of the skin, the hyperosmotic solution being adapted to at least partially absorb into the area of the skin such that the skin becomes generally transparent;
placing an optical readhead over the generally transparent area of the skin;
measuring the amount of light of the analyte using at least one wavelength via the optical readhead; and
calculating the concentration of the analyte from the amount of light.
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Abstract
A non-invasive method of determining the concentration of an analyte comprises topographically applying a hyperosmotic solution to an area of the skin. The hyperosmotic solution is adapted to at least partially absorb into the area of the skin such that the skin becomes generally transparent. An optical readhead is placed over the generally transparent area of the skin. The amount of light of the analyte is measured using at least one wavelength via the optical readhead. The concentration of the analyte is calculated from the amount of light. The analyte may be glucose and the hyperosmotic solution may be glycerol.
156 Citations
27 Claims
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1. A non-invasive method of determining the concentration of an analyte comprising:
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topographically applying a hyperosmotic solution to an area of the skin, the hyperosmotic solution being adapted to at least partially absorb into the area of the skin such that the skin becomes generally transparent;
placing an optical readhead over the generally transparent area of the skin;
measuring the amount of light of the analyte using at least one wavelength via the optical readhead; and
calculating the concentration of the analyte from the amount of light. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A non-invasive method of determining the concentration of glucose comprising:
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topographically applying a hyperosmotic solution to an area of the skin, the hyperosmotic solution being adapted to at least partially absorb into the area of the skin such that the skin becomes generally transparent;
placing an optical readhead over the generally transparent area of the skin;
measuring the amount of light of the glucose using at least one wavelength via the optical readhead; and
calculating the concentration of glucose from the amount of light. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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21. A non-invasive method of determining the concentration of glucose comprising:
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topographically applying glycerol to an area of the skin such that the skin becomes generally transparent;
placing an optical readhead over the generally transparent area of the skin;
measuring the amount of light of the glucose at a mid-infrared wavelength, a near-infrared wavelength or combination thereof via the optical readhead; and
calculating the concentration of the glucose from the amount of light. - View Dependent Claims (22, 23, 24, 25)
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26. A non-invasive method used in calculating the concentration of an analyte comprising:
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topographically applying a hyperosmotic solution to an area of the skin, the hyperosmotic solution being adapted to at least partially absorb into the area of the skin such that the skin becomes generally transparent;
placing an optical readhead over the generally transparent area of the skin; and
measuring the amount of light of the analyte using at least one wavelength via the optical readhead. - View Dependent Claims (27)
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Specification