Method and system for manufacturing biomedical articles, such as using biomedically compatible infiltrant metal alloys in porous matrices
First Claim
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1. A composition for biomedical use which, other than unavoidable impurities, comprises nickel and titanium, wherein the relative proportions by weight of nickel and titanium range from 22 parts nickel 78 parts titanium, to 45 parts nickel 55 parts titanium.
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Abstract
Various elements and alloys selected to achieve both biocompatibility and low melting point for use in infiltrating a porous matrix. The infiltrated porous matrix may be made of ceramic, metal, bioglass, or other suitable material. The infiltrated matrix may be used as a biomedical implant, such as for bone repair and regeneration. The matrix may be manufactured using solid free form fabrication techniques such as three-dimensional printing.
72 Citations
66 Claims
- 1. A composition for biomedical use which, other than unavoidable impurities, comprises nickel and titanium, wherein the relative proportions by weight of nickel and titanium range from 22 parts nickel 78 parts titanium, to 45 parts nickel 55 parts titanium.
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8. A composition for biomedical use which, other than unavoidable impurities, comprises nickel and titanium, wherein the relative proportions by weight of nickel and titanium range from 63.5 parts nickel 36.5 parts titanium, to 67 parts nickel 33 parts titanium.
- 9. A composition for biomedical use which, other than unavoidable impurities, comprises nickel and zirconium, wherein the relative proportions by weight of nickel and zirconium range from 67 parts zirconium 33 parts nickel to 87 parts zirconium 13 parts nickel.
- 14. A composition for biomedical use which, other than unavoidable impurities, comprises nickel and zirconium, wherein the relative proportions by weight of nickel and zirconium range from 41 parts zirconium 59 parts nickel to 54 parts zirconium 46 parts nickel.
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16. A composition for biomedical use which, other than unavoidable impurities, comprises nickel and zirconium, wherein the relative proportions by weight of nickel and zirconium range from 12.5 parts zirconium 87.5 parts nickel to 14 parts zirconium 86 parts nickel.
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17. A composition for biomedical use which, other than unavoidable impurities, comprises nickel and niobium, wherein the relative proportions by weight of nickel and niobium range from 51 parts niobium 49 parts nickel to 53 parts zirconium 47 parts nickel.
- 18. A composition for biomedical use which, other than unavoidable impurities, comprises nickel in a weight fraction of from 60% to 87% and the balance being any one or more of titanium, zirconium and niobium in any combination or proportion.
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20. A composition for biomedical use which, other than unavoidable impurities, comprises a stainless-steel-like alloy and titanium, wherein the relative proportions by weight of stainless-steel-like alloy and titanium range from 12% titanium 88% stainless-steel-like alloy to 20% titanium 80% stainless-steel-like alloy, wherein the stainless-steel-like alloy is defined as any composition containing iron at greater than 50% by weight of the stainless-steel-like alloy, chromium ranging from 10% to 30% by weight of the stainless-steel-like alloy, and nickel ranging from 0 to 20% by weight of the stainless-steel-like alloy.
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21. A composition for biomedical use which, other than unavoidable impurities, comprises a stainless-steel-like alloy and titanium, wherein the relative proportions by weight of stainless-steel-like alloy and titanium range from 60% titanium 40% stainless-steel-like alloy to 80% titanium 20% stainless-steel-like alloy, wherein the stainless-steel-like alloy is defined as any composition containing iron at greater than 50% by weight of the stainless-steel-like alloy, chromium ranging from 10% to 30% by weight of the stainless-steel-like alloy, and nickel ranging from 0 to 20% by weight of the stainless-steel-like alloy.
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22. A composition for biomedical use which, other than unavoidable impurities, comprises a stainless-steel-like alloy and zirconium, wherein the relative proportions by weight of stainless-steel-like alloy and zirconium range from 15% zirconium 85% stainless-steel-like alloy to 25% zirconium 75% stainless-steel-like alloy, wherein the stainless-steel-like alloy is defined as any composition containing iron at greater than 50% by weight of the stainless-steel-like alloy, chromium ranging from 10% to 30% by weight of the stainless-steel-like alloy, and nickel ranging from 0 to 20% by weight of the stainless-steel-like alloy.
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23. A composition for biomedical use which, other than unavoidable impurities, comprises a stainless-steel-like alloy and zirconium, wherein the relative proportions by weight of stainless-steel-like alloy and zirconium range from 60% zirconium 40% stainless-steel-like alloy to 90% zirconium 10% stainless-steel-like alloy, wherein the stainless-steel-like alloy is defined as any composition containing iron at greater than 50% by weight of the stainless-steel-like alloy, chromium ranging from 10% to 30% by weight of the stainless-steel-like alloy, and nickel ranging from 0 to 20% by weight of the stainless-steel-like alloy.
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24. A composition for biomedical use which, other than unavoidable impurities, comprises a stainless-steel-like alloy and niobium, wherein the relative proportions by weight of stainless-steel-like alloy and niobium range from 15% niobium 85% stainless-steel-like alloy to 25% niobium 75% stainless-steel-like alloy, wherein the stainless-steel-like alloy is defined as any composition containing iron at greater than 50% by weight of the stainless-steel-like alloy, chromium ranging from 10% to 30% by weight of the stainless-steel-like alloy, and nickel ranging from 0 to 20% by weight of the stainless-steel-like alloy.
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25. A composition for biomedical use which, other than unavoidable impurities, comprises a stainless-steel-like alloy and niobium, wherein the relative proportions by weight of stainless-steel-like alloy and niobium range from 50% niobium 50% stainless-steel-like alloy to 75% niobium 25% stainless-steel-like alloy, wherein the stainless-steel-like alloy is defined as any composition containing iron at greater than 50% by weight of the stainless-steel-like alloy, chromium ranging from 10% to 30% by weight of the stainless-steel-like alloy, and nickel ranging from 0 to 20% by weight of the stainless-steel-like alloy.
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26. A composition for biomedical use which, other than unavoidable impurities, comprises titanium and zirconium, wherein the relative proportions by weight of titanium and zirconium range from approximately 30 percent zirconium to approximately 70% zirconium.
- 27. A composition for biomedical use which, other than unavoidable impurities, comprises chromium and niobium and nickel, wherein the relative proportions by weight are 20% chromium, 60% nickel, 20% niobium, plus or minus 5% in any of those concentrations.
- 28. A composition for biomedical use which, other than unavoidable impurities, comprises chromium and nickel and titanium, wherein the relative proportions by weight are chromium less than 30%, titanium greater than 10%, nickel greater than 10%.
- 29. A composition for biomedical use which, other than unavoidable impurities, comprises chromium and nickel and titanium, wherein the relative proportions by weight are chromium less than 10%, nickel between 30% and 40%, balance titanium.
- 30. An implant comprising a matrix containing a network of interconnected pores, wherein at least some of the pores are at least partially filled by a biocompatible metal.
- 41. An implant comprising a ceramic matrix containing a network of interconnected pores, wherein at least some of the pores are at least partially filled by a biocompatible metal.
- 57. A bone substitute comprising metal having a composition of 26 from 22 parts nickel 78 parts titanium to 45 parts nickel 55 parts titanium, or from 63.5 parts nickel 36.5 parts titanium to 67 parts nickel 33 parts titanium.
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59. A biomedical article comprising a matrix containing a network of interconnected pores, wherein at least some of the pores are at least partially filled by a biocompatible metal.
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60. A method of manufacturing a biomedical article, comprising:
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manufacturing a matrix having pores;
infusing into the pores an infiltrant which is a metal composition having a melting point less than 1200°
C.; and
allowing the infiltrant to harden. - View Dependent Claims (61, 62, 63, 64, 65, 66)
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Specification