Treatment of disorders by unidirectional nerve stimulation
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Accused Products
Abstract
Apparatus (18) for treating a condition of a subject is provided. An electrode device (100) is adapted to be coupled to longitudinal nervous tissue (40) of the subject, and a control unit (50) is adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition. The control unit is further adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction.
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Citations
254 Claims
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1-59. -59. (canceled)
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68. (canceled)
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71. (canceled)
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85-90. -90. (canceled)
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93. A method for treating a subject, comprising:
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driving into a sympathetic nerve of the subject a current having a characteristic frequency between about 10 and 50 Hz and an amplitude between about 0.1 and 20 mA; and
configuring the driving of the current to be such as to inhibit action potential propagation in the nerve. - View Dependent Claims (94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114)
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115. Apparatus for treating a condition of a subject, comprising:
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an electrode device, adapted to be coupled to longitudinal nervous tissue of the subject; and
a control unit, adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition, and adapted to suppress action potentials from propagating in the nervous tissue in an antidromic direction. - View Dependent Claims (116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 200, 201, 202, 203, 204, 205, 206, 207)
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167-168. -168. (canceled)
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186. (canceled)
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208. Apparatus for treating a subject, comprising:
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an electrode device, adapted to apply current to a sympathetic nerve of the subject; and
a control unit, adapted to;
(a) drive the electrode device to apply to the nerve a current having a characteristic frequency between about 10 and 50 Hz and an amplitude between about 0.1 and 20 mA, and (b) configure the application of the current to be such as to inhibit action potential propagation in the nerve. - View Dependent Claims (209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229)
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230. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises driving the current into tissue selected from the list consisting of;
a pudendal nerve of the subject, a pudendal nerve of the subject, a cavernous nerve of the subject, a spinal nerve root of the subject, and a cervical nerve of the subject.
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231. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises driving the current into a sympathetic nerve of the subject.
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232. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises driving the current into a parasympathetic nerve of the subject.
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233. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises driving the current into a nerve of the subject that provides sympathetic innervation to a heart of the subject.
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234. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises driving the current into a nerve of the subject that provides parasympathetic innervation to a heart of the subject.
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235. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises at least one of;
(a) driving the current into a nerve of the subject that provides sympathetic innervation to a lung of the subject, and (b) driving the current into a nerve of the subject that provides parasympathetic innervation to a lung of the subject, and (c) driving the current into a nerve that modulates hidrosis of the subject.
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236. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises selecting at least one parameter of the current in accordance with a stochastic process.
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237. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises at least one of;
(a) configuring the current to be capable of treating muscle spasm of the subject, and (b) configuring the current to be capable of treating vaginismus of the subject.
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238. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises configuring the current to be capable of treating an aspect of heart failure of the subject.
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239. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises configuring the current to be capable of treating an aspect of cardiac arrhythmia of the subject.
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240. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises configuring the current to be capable of treating tachycardia of the subject.
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241. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises configuring the current to be capable of treating bradycardia of the subject.
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242. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises configuring the current to be capable of treating an aspect of chronic obstructive pulmonary disorder (COPD) of the subject.
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243. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, and comprising implanting electrodes in a vicinity of the nervous tissue, wherein driving the current comprises driving the current through the electrodes on a chronic basis.
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244. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, and comprising placing electrodes in a vicinity of the nervous tissue in response to an acute occurrence, wherein driving the current comprises driving the current through the electrodes, and wherein the method comprises removing the electrodes following the acute occurrence.
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245. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises configuring the current so as to induce action potential propagation primarily in A fibers of the nervous tissue.
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246. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises configuring the current so as to induce action potential propagation primarily in B fibers of the nervous tissue.
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247. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises configuring the current so as to induce action potential propagation primarily in C fibers of the nervous tissue.
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248. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises configuring the current to be capable of treating pain of the subject. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 67)
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249. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein driving the current comprises driving a first current between a cathode and a first anode, which are electrically coupled to respective first and second longitudinal sites of the nervous tissue, wherein suppressing the action potentials comprises driving a second current through the cathode and a second anode, which second anode is electrically coupled to a third site of the nervous tissue, and wherein the first site is disposed between the second and third sites. - View Dependent Claims (69, 70)
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250. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in a second direction, opposite to the first direction, wherein driving the current comprises driving the current into a nerve of the subject that modulates an aspect of sexual functioning of the subject. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
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251. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and
suppressing action potentials from propagating in the nervous tissue in an antidromic direction, wherein suppressing the action potentials comprises applying an electric field to the nervous tissue, wherein applying the field comprises applying a plurality of electric fields to the nervous tissue at respective longitudinal sites thereof, wherein applying the plurality of electric fields to the nervous tissue comprises applying each of the fields at a different respective time, and wherein applying each of the fields at a different respective time comprises applying the fields in sequence, in a progression through the respective longitudinal sites of the nervous tissue. - View Dependent Claims (91, 92)
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252. Apparatus for treating a condition of a subject, comprising:
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an electrode device, adapted to be coupled to longitudinal nervous tissue of the subject; and
a control unit, adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition, and adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction, wherein the electrode device is adapted to apply the current to a nerve of the subject that modulates an aspect of sexual functioning of the subject. - View Dependent Claims (187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199)
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253. A method for treating a condition of a subject, comprising:
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driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction; and
suppressing action potentials from propagating in the nervous tissue in a second direction, opposite to the first direction, wherein driving the current comprises configuring the current to be such as to induce action potentials that travel in the first direction in the nervous tissue and collide with and inhibit natural action potentials propagating in the second direction in the nervous tissue, wherein driving the current comprises configuring the current to be capable of treating pain of the subject, wherein driving the current comprises applying pulses having pulse durations greater than 0.1 milliseconds and less than 2 milliseconds, wherein driving the current comprises applying pulses at at least three sites on the nervous tissue, and setting a frequency of pulse application at each site to be less than 20 Hz, and comprising designating an inter-site spacing separating each of the at least three sites to be at least 1 centimeter.
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254. Apparatus for treating a condition of a subject, comprising:
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an electrode device, adapted to be coupled to longitudinal nervous tissue of the subject; and
a control unit, adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition, and adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction, wherein the control unit is adapted to configure the current to be capable of treating pain of the subject, wherein the control unit is adapted to drive the electrode device to apply to the nervous tissue pulses having pulse durations greater than 0.1 milliseconds and less than 2 milliseconds, wherein the electrode device comprises at least three electrode devices, adapted to be coupled to the nervous tissue at respective sites thereof, and wherein the control unit is adapted to drive each electrode device to apply to the nervous tissue pulses having a frequency less than 20 Hz, and wherein the electrode devices are adapted to be placed at sites having inter-site spacings of at least 1 centimeter.
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Specification
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Current AssigneeMedtronic Incorporated (Medtronic Plc)
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Original AssigneeBioControl Medical (B.C.M) Ltd.
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InventorsCohen, Ehud, Gross, Yossi, Ayal, Shai
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Granted Patent
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Time in Patent OfficeDays
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Field of Search
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US Class Current607/2
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CPC Class CodesA61N 1/0556 Cuff electrodesA61N 1/36007 of urogenital or gastrointe...A61N 1/36114 Cardiac control, e.g. by va...
