Compositions and methods for the treatment and prevention of cancer, angiogenesis, and inflammation
First Claim
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1. A method for treating or preventing a disease or disorder in a mammal comprising:
- administering an agent to the mammal in an amount effective to treat or prevent the disease or disorder wherein the agent binds a sphingolipid or a sphingolipid metabolite and the disease or disorder is selected from the group consisting of;
cancer, angiogenesis, and inflammation.
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Abstract
Methods and compositions are disclosed that are useful for the prevention and/or treatment of cancer, angiogenesis, and inflammation. The beneficial effects of the compositions and methods are achieved through the use of pharmaceutical compositions that include agents that bind spingolipids or sphingolipid metabolites. In one embodiment the agent is an antibody or antibody derivative. In some embodiments, the agent is a receptor of a sphingolipid or a sphingolipid metabolite. Also disclosed are methods for identifying and isolating therapeutic agents.
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Citations
25 Claims
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1. A method for treating or preventing a disease or disorder in a mammal comprising:
administering an agent to the mammal in an amount effective to treat or prevent the disease or disorder wherein the agent binds a sphingolipid or a sphingolipid metabolite and the disease or disorder is selected from the group consisting of;
cancer, angiogenesis, and inflammation.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22)
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16. A method for treating or preventing a disease or disorder in a mammal comprising:
administering an agent to the mammal in an amount effective to treat or prevent the disease or disorder, wherein the agent binds a receptor of a sphingolipid or a sphingolipid metabolite and the disease or disorder is selected from the group consisting of;
cancer, angiogenesis, and inflammation.- View Dependent Claims (23, 24, 25)
Specification