Liposomal vaccine
First Claim
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1. An injectable liposomal composition for delivery of a water-soluble substance, the composition comprising:
- a plurality of liposomal vesicles comprising a high weight ratio of a lipid to an encapsulated water-soluble substance so as to achieve a high efficiency of encapsulation.
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Abstract
The invention provides liposomal vehicles for encapsulating relatively high levels of water-soluble substances including immunogens directed against gastrin and gonadotropin releasing hormone. The liposome encapsulating large amounts of immunogens can be injected parentally to induce effective immune responses without exhibiting significant adverse tissue reactogenicity.
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Citations
51 Claims
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1. An injectable liposomal composition for delivery of a water-soluble substance, the composition comprising:
a plurality of liposomal vesicles comprising a high weight ratio of a lipid to an encapsulated water-soluble substance so as to achieve a high efficiency of encapsulation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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35. A method for producing a liposomal vaccine comprising the steps of:
- preparing phospholipid multilamellar vesicles and encapsulating a water-soluble immunogen or an immunomodulating substance, or both, wherein the liposomes have a high lipid;
protein ratio. - View Dependent Claims (36, 37, 38)
- preparing phospholipid multilamellar vesicles and encapsulating a water-soluble immunogen or an immunomodulating substance, or both, wherein the liposomes have a high lipid;
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39. A liposomal composition of high lipid:
- protein weight ratio comprising an immunogenic construct of immunogenic carrier conjugated to peptide selected from the group consisting of SEQ ID NOS;
17, 18, 19, and 20.
- protein weight ratio comprising an immunogenic construct of immunogenic carrier conjugated to peptide selected from the group consisting of SEQ ID NOS;
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40. A method for producing a liposomal vaccine containing a high dose of immunogen, the method comprising:
rehydrating a lyophilized lipid complement with water or an aqueous ethanol solution, at which step the immunogen is contained either in the lipid complement or the aqueous ethanol solution.
Specification