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Identification of genotype-selective anti-tumor agents

  • US 20040248221A1
  • Filed: 01/29/2004
  • Published: 12/09/2004
  • Est. Priority Date: 01/29/2003
  • Status: Active Grant
First Claim
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1. A method of identifying an agent that is selectively toxic to human tumorigenic cells, comprising:

  • (a) contacting test cells, which are engineered human tumorigenic cells, with a candidate agent;

    (b) determining viability of test cells contacted in (a) with the candidate agent; and

    (c) comparing the viability of test cells determined in (b) with an appropriate control, wherein if the viability of the test cells is less than that of the control cells, then an agent that is selectively toxic to engineered human tumorigenic cells is identified.

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