Multi-array systems and methods of use thereof
First Claim
Patent Images
1. A multi-array system, comprising:
- a first solid substrate having a first surface;
a second solid substrate having a second surface, wherein the first and second solid substrates are positioned so that the first surface faces the second surface;
a spacer contacting and separating the first and second solid substrates, so as to form at least one reaction chamber comprising a fluid-receiving space between the first and second surfaces, a first biomolecule array immobilized on the first surface; and
a second biomolecule array immobilized on the second surface, wherein the first and second biomolecule arrays are exposed to the fluid-receiving space.
2 Assignments
0 Petitions
Accused Products
Abstract
Multi-array systems useful for performing assays on multiple biomolecule arrays simultaneously while minimizing sample volume are provided. Apparatuses and kits comprising the multi-array systems also provided. Methods of using the multi-array systems in assays such as hybridization arrays are also provided, as well as methods of producing the multi-array systems.
-
Citations
31 Claims
-
1. A multi-array system, comprising:
-
a first solid substrate having a first surface;
a second solid substrate having a second surface, wherein the first and second solid substrates are positioned so that the first surface faces the second surface;
a spacer contacting and separating the first and second solid substrates, so as to form at least one reaction chamber comprising a fluid-receiving space between the first and second surfaces, a first biomolecule array immobilized on the first surface; and
a second biomolecule array immobilized on the second surface, wherein the first and second biomolecule arrays are exposed to the fluid-receiving space. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 30, 31)
-
-
29. A method of making a multi-array system, comprising the steps of:
-
providing a first substrate having a first surface, wherein a first biomolecule array is immobilized on the first surface;
providing a second solid substrate having a second surface, wherein a second biomolecule array is immobilized on the second surface; and
fixably positioning the first and second solid substrates using a spacer so as to form a reaction chamber in which the first and second surfaces face each other and are separated by a fluid-receiving space, and in which the first and second biomolecule arrays are exposed to the fluid-receiving space.
-
Specification